IMI – Clinical myopia control trials and instrumentation report

TitleIMI – Clinical myopia control trials and instrumentation report
Publication TypeJournal Article
Year of Publication2019
AuthorsWolffsohn, J. S., P. S. Kollbaum, D. A. Berntsen, D. A. Atchison, A. Benavente, A. Bradley, H. Buckhurst, M. Collins, T. Fujikado, T. Hiraoka, M. Hirota, D. Jones, N. S. Logan, L. Lundström, H. Torii, S. A. Read, and K. Naidoo
JournalInvestigative Ophthalmology and Visual Science
Keywordsaccommodation paralysis, anisometropia, Article, Astigmatism, best corrected visual acuity, Clinical trial guidelines, comet assay, Cornea, evidence based practice, eye axis length, eye movement, eye refraction, Glaucoma, human, Instrumentation, intraocular pressure, masking, myopia, Myopia control, Myopia progression, patient compliance, patient-reported outcome, priority journal, pupil, randomization, Recommendations, refraction error, sclera, stratification, ultrasound, Visual acuity, visual impairment
AbstractThe evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes were classified as primary (refractive error and/or axial length), secondary (patient reported outcomes and treatment compliance), and exploratory (peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/ lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently available instrumentation, which the literature has shown to best achieve the primary and secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient selection were also identified. These findings and consensus from the International Myopia Institute members led to final recommendations to inform future instrumentation development and to guide clinical trial protocols. © 2019 The Authors.