Imi – Report on experimental models of emmetropization and myopia

TitleImi – Report on experimental models of emmetropization and myopia
Publication TypeJournal Article
Year of Publication2019
AuthorsTroilo, D., E. Smith, III, D. Nickla, R. Ashby, A. Tkatchenko, L. Ostrin, T. Gawne, M. Pardue, J. Summers, C. Kee, F. Schroedl, S. Wahl, and L. Jones
JournalInvestigative Ophthalmology and Visual Science
Volume60
PaginationM31-M88
Keywordsaccommodation paralysis, Animal models, Article, Callitrichinae, chick, choroidal thickness, circadian rhythm, disease exacerbation, emmetropia, emmetropization, environmental factor, extracellular matrix, Eye growth, gene expression, guinea pig, heredity, human, melanopsin, mouse, myopia, nonhuman, Optical coherence tomography, priority journal, refraction error, retinal pigment epithelium, retinoic acid, Tupaiidae, Visual acuity, visual evoked potential, Visual regulation, zebra fish
Abstract

The results of many studies in a variety of species have significantly advanced our understanding of the role of visual experience and the mechanisms of postnatal eye growth, and the development of myopia. This paper surveys and reviews the major contributions that experimental studies using animal models have made to our thinking about emmetropization and development of myopia. These studies established important concepts informing our knowledge of the visual regulation of eye growth and refractive development and have transformed treatment strategies for myopia. Several major findings have come from studies of experimental animal models. These include the eye’s ability to detect the sign of retinal defocus and undergo compensatory growth, the local retinal control of eye growth, regulatory changes in choroidal thickness, and the identification of components in the biochemistry of eye growth leading to the characterization of signal cascades regulating eye growth and refractive state. Several of these findings provided the proofs of concepts that form the scientific basis of new and effective clinical treatments for controlling myopia progression in humans. Experimental animal models continue to provide new insights into the cellular and molecular mechanisms of eye growth control, including the identification of potential new targets for drug development and future treatments needed to stem the increasing prevalence of myopia and the vision-threatening conditions associated with this disease. © 2019 The Authors.

DOI10.1167/iovs.18-25967