Multicenter testing of a risk assessment survey for soft contact lens wearers with adverse events: A contact lens assessment in youth study

TitleMulticenter testing of a risk assessment survey for soft contact lens wearers with adverse events: A contact lens assessment in youth study
Publication TypeJournal Article
Year of Publication2018
AuthorsSorbara, L., A. Zimmerman, G. Mitchell, K. Richdale, D. Lam, B. Kinoshita, R. Chalmers, and H. Wagner
JournalEye and Contact Lens
Keywordsadolescent, adult, adverse device effect, adverse event, age, age distribution, Age Factors, Article, clinical trial, comparative study, contact lens related corneal inflammation, Contact lenses, controlled study, Corneal inflammatory event, female, follow up, health care survey, high risk behavior, human, Humans, Hydrophilic, hydrophilic contact lens, incidence, Inflammatory events, Internet, keratitis, major clinical study, male, multicenter study, Ontario, Overnight wear, patient care, patient education, procedures, prognosis, questionnaire, refraction error, Refractive Errors, reproducibility, Reproducibility of Results, risk assessment, risk factor, Risk factors, Serious and significant contact lens events, Sex Distribution, sex factor, Sex Factors, sex ratio, Surveys and Questionnaires, United States, young adult

Purpose: To test the ability of responses to the Contact Lens Assessment in Youth (CLAY) Contact Lens Risk Survey (CLRS) to differentiate behaviors among participants with serious and significant (S&S) contact lens-related corneal inflammatory events, those with other events (non-S&S), and healthy controls matched for age, gender, and soft contact lens (SCL) wear frequency. Methods: The CLRS was self-administered electronically to SCL wearers presenting for acute clinical care at 11 clinical sites. Each participant completed the CLRS before their examination. The clinician, masked to CLRS responses, submitted a diagnosis for each participant that was used to classify the event as S&S or non-S&S. Multivariate logistic regression analyses were used to compare responses. Results: Comparison of responses from 96 participants with S&S, 68 with non-S&S, and 207 controls showed that patients with S&S were more likely (always or fairly often) to report overnight wear versus patients with non-S&S (adjusted odds ratio [aOR], 5.2; 95% confidence interval [CI], 1.4-18.7) and versus controls (aOR, 5.8; CI, 2.2-15.2). Patients with S&S were more likely to purchase SCLs on the internet versus non-S&S (aOR, 4.9; CI, 1.6-15.1) and versus controls (aOR, 2.8; CI, 1.4-5.9). The use of two-week replacement lenses compared with daily disposables was significantly higher among patients with S&S than those with non-S&S (aOR, 4.3; CI, 1.5-12.0). Patients with S&S were less likely to regularly discard leftover solution compared with controls (aOR, 2.5; CI, 1.1-5.6). Conclusions: The CLRS is a clinical survey tool that can be used to identify risky behaviors and exposures directly associated with an increased risk of S&S events. © 2016 Contact Lens Association of Ophthalmologists