The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

TitleThe Ontario Neurodegenerative Disease Research Initiative (ONDRI)
Publication TypeJournal Article
Year of Publication2017
AuthorsFarhan, S., R. Bartha, S. E. Black, D. Corbett, E. Finger, M. Freedman, B. Greenberg, D. Grimes, R. Hegele, C. Hudson, P. Kleinstiver, A. Lang, M. Masellis, W. McIlroy, P. McLaughlin, M. Montero-Odasso, D. Munoz, D. Munoz, S. Strother, R. Swartz, S. Symons, M. Tartaglia, L. Zinman, and M. Strong
JournalCanadian Journal of Neurological Sciences
Volume44
Pagination196-202
KeywordsAlzheimer disease, Alzheimer's, Amyotrophic Lateral Sclerosis, Article, attention, bioinformatics, cerebrovascular disease, cognition, cognitive defect, data collection method, degenerative disease, Dementia, diffusion tensor imaging, discourse analysis, executive function, eye tracking, Frontotemporal Dementia, functional magnetic resonance imaging, functional neuroimaging, gait, genomics, human, Humans, intelligence, language, Longitudinal Studies, longitudinal study, major clinical study, memory, metacognition, mild cognitive impairment, Neurodegeneration, Neurodegenerative Diseases, neuropathology, neuropsychology, nuclear magnetic resonance imaging, nuclear magnetic resonance scanner, observational study, Ontario, Parkinson Disease, personality, priority journal, retina, sensory evaluation, spectral domain optical coherence tomography, speech, theory of mind, vascular cognitive impairment, Vision, working memory
Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource. Copyright © The Canadian Journal of Neurological Sciences Inc. 2016Â This is an open access article, distributed under the terms of the creative commons attribution licence.

DOI10.1017/cjn.2016.415