Orientation tuning and contrast dependence of continuous flash suppression in amblyopia and normal vision

TitleOrientation tuning and contrast dependence of continuous flash suppression in amblyopia and normal vision
Publication TypeJournal Article
Year of Publication2018
AuthorsGao, T., T. Ledgeway, A. Lie, N. Anstice, J. Black, P. McGraw, and B. Thompson
JournalInvestigative Ophthalmology and Visual Science
Volume59
Pagination5462-5472
Keywordsadult, Amblyopia, analysis of variance, Article, Binocular, binocular vision, blood patch, clinical article, Continuous flash suppression, contrast enhancement, Contrast sensitivity, controlled study, disease severity assessment, Dominance, eye dominance, eye refraction, female, human, Humans, interocular suppression, interocular transfer, male, middle aged, molecular pathology, Ocular, orientation, pathophysiology, perceptive threshold, performance, Photic Stimulation, photostimulation, physiology, priority journal, psychophysics, refraction error, retinoscopy, Sensory Thresholds, spatiotemporal analysis, strabismus, task performance, tuning curve, Vision, Visual acuity, visual orientation, young adult
Abstract

PURPOSE. Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls. METHODS. Nine patients (mean age, 26.9 ± SD 4.7 years) and 11 controls (mean age, 24.8 ± SD 5.3 years) participated. In the CFS paradigm, spatially one-dimensional noise refreshing at 10 Hz was displayed in one eye to induce suppression of the other eye, and suppression strength was measured by using a grating contrast increment detection task. In experiment 1, noise contrast was fixed and the orientation difference between the noise and the grating was varied. In experiment 2, noise and grating orientations were identical and noise contrast was varied. RESULTS. Suppression patterns varied in both groups. In experiment 1, controls showed consistently orientation-tuned CFS (mean half-height bandwidth, 35.88 ± SD 21.58) with near-equal strength between eyes. Five of nine patients with amblyopia exhibited orientation-independent CFS. Eight patients had markedly unequal suppression between eyes. Experiment 2 found that increasing the noise contrast to the amblyopic eye may produce suppression of the fellow eye, but suppression remained unequal between eyes. CONCLUSIONS. Our data revealed that orientation specificity in CFS was very broad or absent in some patients with amblyopia, which could not be predicted by clinical measures. Suppression was unbalanced across the entire contrast range for most patients. This suggests that abnormal early visual experience disrupts the development of interocular suppression mechanisms. © 2018 The Authors.

DOI10.1167/iovs.18-23954