Retinal Oxygen Saturation in Patients with Primary Open-angle Glaucoma Using a Non-flash Hypespectral Camera

TitleRetinal Oxygen Saturation in Patients with Primary Open-angle Glaucoma Using a Non-flash Hypespectral Camera
Publication TypeJournal Article
Year of Publication2017
AuthorsShahidi, A., C. Hudson, F. Tayyari, and J. Flanagan
JournalCurrent eye research
Volume42
Pagination557-561
Keywordsaged, Article, blood, blood flow, blood flow velocity, blood oxygen tension, clinical article, comparative study, controlled study, devices, diastolic blood pressure, female, Glaucoma, Healthy Volunteers, human, Humans, hyperspectral retinal camera, Image processing, intraocular pressure, male, nerve cell degeneration, normal human, open angle glaucoma, Open-Angle, ophthalmic camera, optic nerve, optical density, oximetry, oxygen, oxygen consumption, pathophysiology, perimetry, photography, physiology, primary open-angle glaucoma, priority journal, Regional Blood Flow, retina blood vessel, retina vein, retinal oxygen saturation, Retinal Vessels, systolic blood pressure, visual field, visual field defect, Visual Field Tests, Visual Fields
Abstract

Purpose/Aim: To investigate retinal vessel blood oxygen saturation in patients with primary open-angle glaucoma (POAG) and healthy controls.Materials and Methods: A novel non-flash hyperspectral retinal camera was used to image 17 healthy individuals (mean age 69.3 ± 6.1 years) and 22 patients with stable POAG (mean age 69.2 ± 5.8 years) at 548, 569, 586, 600, 605, and 610 nm wavelengths. POAG patients were grouped as mild–moderate (n = 13) and moderate–severe (n = 9) based on Humphrey 24-2 visual field results (mean deviation [MD] 0.06 for all). However, mean venular SO2 was significantly higher in the POAG with MD ≥ −6 dB when compared to controls and patients with mild glaucoma (p = 0.005). The AV differences were significantly lower in patients with more severe field defect (p = 0.006) compared to the remaining groups. No differences were found in the mean arteriolar SO2 between the groups (p = 0.155). Significant correlations were found only between higher visual field MD values and higher venular SO2 (p = 0.048) but not the remaining SO2 measurements. Conclusion: Patients with POAG and moderate–severe visual field defect had higher venular SO2 compared to those with mild–moderate defect and controls. This would indicate reduced oxygen consumption in more advanced glaucoma likely as a result of ganglion cell degeneration. © 2017 Taylor & Francis.

DOI10.1080/02713683.2016.1217544