Retinal perfusion changes in radiation retinopathy

TitleRetinal perfusion changes in radiation retinopathy
Publication TypeJournal Article
Year of Publication2018
AuthorsRose, K., H. Krema, P. Durairaj, W. Dangboon, Y. Chavez, S. Kulasekara, and C. Hudson
JournalActa Ophthalmologica
Volume96
Paginatione727-e731
Keywordsadult, arteriolar oxygen saturation, Article, blood flow, blood oxygen tension, brachytherapy, choroid melanoma, Choroid Neoplasms, choroid tumor, choroidal melanoma, clinical article, complication, controlled study, diagnostic imaging, diastolic blood pressure, disease exacerbation, Disease Progression, eye fundus, female, Fluorescein Angiography, fluorescence angiography, Fundus Oculi, heart rate, human, Humans, hyperspectral retinal camera, iodine 125, ionizing radiation, melanoma, middle aged, Optical Coherence, Optical coherence tomography, oxygen saturation, pathophysiology, perfusion, physiology, priority journal, procedures, Radiation Injuries, radiation injury, radiation response, radiation retinopathy, Regional Blood Flow, retina blood flow, retina blood vessel, retina disease, retinal blood flow, Retinal Diseases, retinal perfusion, Retinal Vessels, Retinopathy, spectral domain optical coherence tomography, systolic blood pressure, Tomography, venular oxygen saturation
Abstract

Purpose: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma. Methods: Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control. Both eyes underwent measurement of total retinal blood flow (TRBF) and retinal blood oxygen saturation using prototype methodologies of Doppler Spectral Domain Optical Coherence Tomography (OCT) and Hyperspectral Retinal Camera, respectively. Results: The average TRBF in the retinopathy eye was significantly lower compared to the fellow eye (33.48 ± 12.73 μl/min versus 50.37 ± 15.26 μl/min; p = 0.013). The arteriolar oxygen saturation (SaO2) and venular oxygen saturation (SvO2) were higher in the retinopathy eye compared to the fellow eye (101.11 ± 4.26%, versus 94.45 ± 5.79%; p = 0.008) and (62.96 ± 11.05% versus 51.24 ± 6.88%, p = 0.051), respectively. Conclusion: The ionizing radiation seems to have an impact on the TRBF, SaO2 and SvO2, clinically presenting similar to a rapidly developing diabetic retinopathy. The results show an altered retinal vascular physiology in patients with radiation-related retinopathy. © 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd

DOI10.1111/aos.13797