Tear osmolarity changes after use of hydroxypropyl-guar-based lubricating eye drops

TitleTear osmolarity changes after use of hydroxypropyl-guar-based lubricating eye drops
Publication TypeJournal Article
Year of Publication2018
AuthorsNg, A., A. Keech, and L. Jones
JournalClinical Ophthalmology
Keywordsadult, aged, Article, artificial tear, clinical article, conjunctival hyperemia, controlled study, cornea disease, Corneal staining, drug efficacy, Dry eye, Eye drop, feasibility study, female, follow up, HP-guar, human, hydroxypropyl guar based lubricating eye drop, macrogol 400, male, non invasive tear break up time, Ocular Surface Disease Index, open study, Osmolarity, outcome assessment, prospective study, systane ultra, tear film, tear osmolarity, treatment duration, unclassified drug, visual system parameters

Purpose: To evaluate tear osmolarity after using a hydroxypropyl-guar (HP-guar)-based lubricating eye drop four times daily (QID) for 3 weeks. Methods: Thirty-one participants with dry eye disease (Ocular Surface Disease Index [OSDI] score ≥20 and tear osmolarity ≥300 mOsm/L in at least one eye) were enrolled in this prospective, dispensing, non-randomized study involving a baseline visit and 3‑week follow-up. Tear osmolarity, non-invasive tear break up time (NITBUT), conjunctival hyperemia, corneal and conjunctival staining were determined at baseline. Participants were instructed to instill one drop of a HP-guar-based drop QID in each eye for 3 weeks. At the follow-up visit, the symptoms and ocular surface parameters were reassessed. At this visit, one HP-guar drop was instilled into each eye and osmolarity was measured after 15 minutes, to examine short-term changes in osmolarity. Results: Twenty-eight participants completed the study (5M, 23F; median age 54 yrs, range 25-83 yrs). At baseline, mean OSDI score was 44.9±15.2 and mean osmolarities were 314.63±11.9/306.6±10.1 mOsm/L (worst eye [WE]/better eye [BE]). After 3 weeks, mean osmolarity reduced to 307.7±15.7/303.9±11.3 mOsm/L (WE/BE; p0.05). Conclusions: A significant reduction in tear osmolarity and improvements in dry eye symptoms, corneal staining, and NITBUT were observed after 3 weeks of QID use of a HP-guar-based lubricant drop. A decrease in osmolarity was also demonstrated 15 minutes after drop instillation. © 2018 Ng et al.