Twenty-four hour intraocular pressure monitoring with the SENSIMED Triggerfish contact lens: Effect of body posture during sleep

TitleTwenty-four hour intraocular pressure monitoring with the SENSIMED Triggerfish contact lens: Effect of body posture during sleep
Publication TypeJournal Article
Year of Publication2017
AuthorsBeltran-Agulló, L., Y. Buys, F. Jahan, C. Shapiro, J. Flanagan, J. Cheng, and G. Trope
JournalBritish Journal of Ophthalmology
Keywords80 and over, adult, aged, Article, body position, clinical article, comparative study, contact lens, Contact lenses, controlled study, Cross-Over Studies, crossover procedure, devices, Diagnostic tests/Investigation, female, Glaucoma, human, Humans, intraocular pressure, iridotomy, low tension glaucoma, male, middle aged, Ocular, oculoplethysmography, open angle glaucoma, open study, optic nerve, pathophysiology, phacoemulsification, physiology, Posture, priority journal, procedures, Prospective Studies, prospective study, randomized controlled trial, sleep, sleep waking cycle, Tonometry, trabeculectomy, trabeculoplasty, very elderly, wakefulness

Purpose: To determine the difference in relative intraocular pressure (IOP) measured by the SENSIMED Triggerfish (TF) contact lens in flat compared with 30° head-up sleeping positions in patients with progressive primary open-angle glaucoma or normotensive glaucoma, based on recent or recurrent disc haemorrhage. Design: Prospective, randomised, cross-over, open-label comparative study. Methods: IOP was monitored for 24 hours using TF on two separate sessions. Patients were randomly assigned to sleep flat one night and 30° head-up the other. Outputs in arbitrary units were obtained. Sleep and wake periods were defined as 22:00-6:00 and 8:00-22:00, respectively. Mean TF values during sleep and wake periods and wake-sleep and sleep-wake slopes were calculated for each session. TF output signals were compared between positions. Results: Twelve subjects completed the study. Significant mean positive slopes were noted during the sleep period for both positions (p50% of the subjects requires further investigation to establish whether the increased output values over time are an artefact induced by the TF or a real change in IOP. © Published by the BMJ Publishing Group Limited.