Uptake and Release of Polyvinyl Alcohol from Hydrogel Daily Disposable Contact Lenses

TitleUptake and Release of Polyvinyl Alcohol from Hydrogel Daily Disposable Contact Lenses
Publication TypeJournal Article
Year of Publication2019
AuthorsPhan, C., L. Subbaraman, and L. Jones
JournalOptometry and Vision Science
Volume96
Pagination180-186
Date PublishedMAR
ISBN Number1040-5488
Abstract

{SIGNIFICANCE Polyvinyl alcohol is a wetting agent that could reduce the symptoms of dry eye and contact lens discomfort. Currently, only one lens type, nelfilcon A (DAILIES AquaComfort Plus), releases polyvinyl alcohol. The concept of releasing this agent from contact lenses could be applied to other lens materials. PURPOSE The purpose of this study was to measure the release of polyvinyl alcohol from commercially available hydrogel daily disposable contact lenses using refractive index and iodine-borate methods. METHODS Etafilcon A, omafilcon A, and nelfilcon A were soaked in phosphate-buffered saline and 0.2% trifluoroacetic acid/acetonitile for 24 hours to remove residual blister pack components. The lenses were then incubated in a 10-mg/mL solution of polyvinyl alcohol for 24 hours. After the incubation period, the lenses were placed in 2 mL of phosphate-buffered saline. At specified time intervals

DOI10.1097/OPX.0000000000001351