Validation of the UNC OCT index for the diagnosis of early glaucoma

TitleValidation of the UNC OCT index for the diagnosis of early glaucoma
Publication TypeJournal Article
Year of Publication2018
AuthorsMwanza, J. - C., G. Lee, D. Budenz, J. Warren, M. Wall, P. Artes, T. Callan, and J. Flanagan
JournalTranslational Vision Science and Technology
Keywordsadult, aged, Article, comparative study, controlled study, Early glaucoma, Glaucoma, human, intraocular pressure, major clinical study, nerve cell, optic disk, Optical coherence tomography, radiological parameters, retinal nerve fiber layer, scoring system, sensitivity and specificity, Tonometry, UNC OCT index, University of North Carolina Optical Coherence Tomography Index, validation study, very elderly, visual field

{Purpose: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. Methods: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than -4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study. CIRRUS OCT average and quadrants’ retinal nerve fiber layer (RNFL); optic disc vertical cup-to-disc ratio (VCDR), cup-to-disc area ratio, and rim area; and average, minimum, and six sectoral ganglion cell-inner plexiform layer (GCIPL) measurements were run through the UNC OCT Index algorithm. Area under the receiver operating characteristic curve (AUC) and sensitivities at 95% and 99% specificity were calculated and compared between single parameters and the UNC OCT Index. Results: Mean age was 60.1 ± 11.0 years for normal subjects and 66.5 ± 8.1 years for glaucoma patients (P < 0.001). MD was 0.29 ± 1.04 dB and -1.30 ± 1.35 dB in normal and glaucomatous eyes (P < 0.001), respectively. The AUC of the UNC OCT Index was 0.96. The best single metrics when compared to the UNC OCT Index were VCDR (0.93