Alzheimer's disease - a medicinal chemistry approach
We are honoured to invite Assistant Professor Praveen Nekkar to speak in the Pharmacy Research Seminar Series.
Visitors from main campus and those external to Waterloo are welcome.
Please RSVP to email@example.com.
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by loss of memory, cognition and dementia. Unfortunately, the current pharmacotherapy options are limited and are not a long term treatment option. The pathophysiology of AD is complex and is not clearly understood. Some major hypotheses on AD include the cholinergic dysfunction, amyloid cascade, tau hyperphosphorylation and oxidative stress. The Nekkar Rao lab’s research focus is on Medicinal Chemistry based drug design aimed at developing small molecules to target the cholinergic, amyloid, tau and oxidative stress pathways associated with AD as potential pharmacological tools to study and treat AD.
The goal is to develop small molecules as potential disease modifying agents with ability to target multiple pathways associated with AD pathophysiology as opposed to the traditional “one drug, one target” approach.
Specific examples on novel ring system design, their synthesis and biological evaluation results will be discussed. Other examples include case studies to understand the bind modes of some known natural products with anti-amyloid aggregation properties. In summary, these investigations have shown that Medicinal Chemistry principles can be used to develop hybrid small molecules to target multiple pathways associated with AD as potential therapies.