University of Waterloo
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32215
Fax: (519) 746-8115
Quantum Neurobiology Group
BSRC Alexander Fleming,
General anesthetics were first used 170 years ago, revolutionised medicine and enable 200M+ surgical procedures yearly to be carried out with impressive safety. Yet we do not really know how general anesthetics work. Theories have come and gone over the years without ever definitively establishing their place and mode of action. In my talk I shall give a brief historical overview of this fascinating puzzle, propose a novel mechanism, and show some evidence from our recent ESR experiments on fruit flies using anesthetic-resistant mutants. These suggest that electrons flowing in a long-standing and hitherto largely discredited contender —mitochondria— may actually play a central role in anesthesia.
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Indigenous Initiatives Office.