Enhancing Optical Molecular Imaging with Controlled Laser FieldsExport this event to calendar

Thursday, March 15, 2012 — 3:30 PM to 5:00 PM EDT

Physics colloquium

Speaker: 
Warren S. Warren
Speaker's Institute: 
Duke University

Enhancing Optical Molecular Imaging with Controlled Laser Fields

Molecular imaging - use of chemical signatures to image function instead of merely structure - promises to enable a new generation of clinical modalities that can revolutionize both diagnosis and treatment. Many approaches use targeted contrast agents, but that raises serious issues about human safety and barriers to clinical approval. Instead, our work focuses on development of methods which maximize intrinsic contrast, generally using enhanced control over the probing radiation fields. In optical imaging, our lab has developed advanced femtosecond pulse shaping and detection technologies to access intrinsic nonlinear signatures that were not previously observable in tissue. For example, shaped femtosecond pulses and femtosecond pulse trains can measure nonlinear absorption even in the absence of fluorescence; can quantify self-phase or cross-phase modulation; or can use differences in excited state and ground state dynamics to achieve molecular specificity with microscopic resolution, even in highly scattering media. In all these cases enhanced control over the optical field permits microscopic resolution imaging, much deeper than is possible with conventional microscopy, and enables detection of novel and clinically relevant contrast.

Applications to imaging hemoglobins and melanins in tissue by nonlinear absorption will be highlighted, including recent work published in Science Translational Medicine which could revolutionize melanoma diagnosis by improving the pathology “gold standard.” I will also show extensions of this approach to imaging through opaque pigments in centuries-old artwork, which lets us quantify impurities, identify pigment origin, and see through discolored binder to determine the original artist’s intent.

S M T W T F S
27
28
29
30
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
  1. 2021 (24)
    1. September (1)
    2. August (1)
    3. July (6)
    4. June (5)
    5. May (3)
    6. April (2)
    7. March (5)
    8. February (1)
  2. 2020 (36)
    1. November (3)
    2. October (6)
    3. September (3)
    4. August (1)
    5. July (1)
    6. June (2)
    7. April (1)
    8. March (6)
    9. February (5)
    10. January (8)
  3. 2019 (106)
  4. 2018 (124)
  5. 2017 (110)
  6. 2016 (99)
  7. 2015 (85)
  8. 2014 (74)
  9. 2013 (88)
  10. 2012 (81)