Imaging myelin in vivo using magnetic resonance imaging Export this event to calendar

Thursday, November 22, 2012 — 4:00 PM to 5:00 PM EST

Alex MacKay
Professor and Director of the MRI Research Centre
Department of Physics and Astronomy, and Department of Radiology
University of British Columbia

Abstract

Myelin provides the insulation on neuronal axons in brain; it enables salutatory conduction which speeds up the propagation velocities of nerve signals by more than an order of magnitude. Myelination plays a large role in neurodevelopment and myelin disorders are associated with several neurodegenerative diseases, including multiple sclerosis. The microscopic environment for water in myelin differs substantially from the local environment of water in the intra- and extra- cellular spaces; consequently, the magnetic resonance signal from water in myelin can be distinguished from the signal from the rest of the water in central nervous system tissue. The myelin water signal can be used as an in vivo myelin marker in humans and in animal models of human disease. Results will be presented from measurements of myelin water in normal volunteers as well as in subjects who suffer from multiple sclerosis, phenylketonuria and dyslexia.

Location 
PHY - Physics
150
200 University Avenue West

Waterloo, ON N2L 3G1
Canada

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