University of Waterloo
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32215
Fax: (519) 746-8115
Measurements of the optical quality of the eye have increased in precision and repeatability as a result of adaptive optics techniques adapted from astronomy. We have used these techniques to identify signals to the direction of eye growth which are up regulated in the presence of myopia (short-sightednesss), induced by defocussing lenses. These and other optical changes measured in myopia have led to a greater interest in the role of the optics of the eye in understanding and treating myopia. As well as measuring the optical quality more precisely, we can correct optical blur and acquire high resolution in vivo images of individual retinal cells. We are using this instrumentation to explore the earliest ocular changes in Type I diabetes and changes in degenerative diseases affecting the cone photoreceptors of the human eye. This may lead to earlier and improved interventions in these diseases. I will also briefly discuss the potential use of precisely focussed light in the treatment of ocular disease. Currently, definitive diagnosis of Alzheimer’s disease only occurs after death. Amyloid beta, a protein marker which produces plaques is found in the brains of those with the disease. Recently we have confirmed the presence of amyloid in the ex vivo neural retina of those with the disease and not in age matched normal subjects without the disease. We are developing an in vivo polarization imaging technique which creates contrast of the deposits against the surrounding retina without the use of a dye. We hope that this will become a more accessible, less invasive and less expensive technique than others under development for the diagnosis of Alzheimer’s disease.
Melanie Campbell is currently a Professor of Physics and Astronomy and in the School of Optometry and Vision Science at the University of Waterloo. She earned a BSc in Chemical Physics, University of Toronto, an MSc in Physics, University of Waterloo and, from the Australian National University, a PhD in Applied Mathematics and Physiology. Following a CSIRO Fellowship at the Institute of Mathematics and Statistics in Canberra, Campbell returned to Canada with an NSERC University Research Fellowship. Prof. Campbell undertakes experimental and theoretical research in the optical quality of the eye and improved imaging of its structures. She studies eye development, eye disease and linear and nonlinear optics of the eye. Campbell is known for her work on the gradient index optics of the crystalline lens, its changes with ageing and effects of visual experience on its refractive index distribution. Recently she has discovered possible optical signals to eye growth which appear to follow a circadian rhythm. She collaborated in the first real-time images of cones at the rear of the eye, using adaptive optics. Applications of interest include non-invasive imaging of the eye for the diagnosis of Alzheimer’s Disease, using the retina as a window on the brain. Campbell is a Fellow of the Optical Society of America, a Fellow of the Institute of Physics (UK) and is a former President of the Canadian Association of Physicists. Campbell was also a co-founder of Biomedical Photometrics Inc, now Huron Technologies. Campbell shared the 2004 Rank Prize in Optoelectronics for her work cited as "an initial idea (that) has been carried through to practical applications that have, or will, demonstrably benefit mankind.” She was awarded the 2014 CAP-INO Medal for Outstanding Achievement in Applied Photonics “for her unique contribution to apply the methods of polarization and adaptive optics to the understanding of eye functioning and eye diseases. Among others, her contributions to a better understanding of short-sightedness and to improve retina imaging are likely to have a major impact on the diagnosis and treatment of several eye diseases.”
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is centralized within our Office of Indigenous Relations.