University of Waterloo
200 University Avenue West
Waterloo, Ontario, Canada N2L 3G1
Phone: (519) 888-4567 ext 32215
Fax: (519) 746-8115
Ohio State University
Ultraviolet irradiation causes DNA damages and leads to genome mutation and potential skin cancer. However, such damage can be restored completely by photolyase enzymes in nature with blue light. Using femtosecond spectroscopy and molecular biology, we report here the real-time studies of complete repair processes at the most fundamental level and thus reveal the repair photocycle and elucidate the molecular mechanism.