@article {21913,
	title = {Recent advances in engineering propionyl-CoA metabolism for microbial production of value-added chemicals and biofuels},
	journal = {Critical Reviews in Biotechnology},
	volume = {37},
	number = {6},
	year = {2017},
	note = {Srirangan, Kajan Bruder, Mark Akawi, Lamees Miscevic, Dragan Kilpatrick, Shane Moo-Young, Murray Chou, C. Perry},
	pages = {701-722},
	abstract = {Diminishing fossil fuel reserves and mounting environmental concerns associated with petrochemical manufacturing practices have generated significant interests in developing whole-cell biocatalytic systems for the production of value-added chemicals and biofuels. Although acetylCoA is a common natural biogenic precursor for the biosynthesis of numerous metabolites, propionyl-CoA is unpopular and non-native to most organisms. Nevertheless, with its C3-acyl moiety as a discrete building block, propionyl-CoA can serve as another key biogenic precursor to several biological products of industrial importance. As a result, engineering propionyl-CoA metabolism, particularly in genetically tractable hosts with the use of inexpensive feedstocks, has paved an avenue for novel biomanufacturing. Herein, we present a systematic review on manipulation of propionyl-CoA metabolism as well as relevant genetic and metabolic engineering strategies for microbial production of value-added chemicals and biofuels, including odd-chain alcohols and organic acids, bio(co) polymers and polyketides. [GRAPHICS] .},
	author = {Srirangan, K. and Bruder, M. and Akawi, L. and Miscevic, D. and Kilpatrick, S. and Moo-Young, M. and Chou, C. P.}
}
