<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irini Sotiri</style></author><author><style face="normal" font="default" size="100%">Matthew Robichaud</style></author><author><style face="normal" font="default" size="100%">David Lee</style></author><author><style face="normal" font="default" size="100%">Steffen Braune</style></author><author><style face="normal" font="default" size="100%">Maud Gorbet</style></author><author><style face="normal" font="default" size="100%">Buddy D. Ratner</style></author><author><style face="normal" font="default" size="100%">John L. Brash</style></author><author><style face="normal" font="default" size="100%">Robert Latour</style></author><author><style face="normal" font="default" size="100%">Ilya Reviakine</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">BloodSurf 2017: News from the blood-biomaterial frontier</style></title><secondary-title><style face="normal" font="default" size="100%">Acta Biomaterialia</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1016/j.actbio.2019.01.032</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">87</style></volume><pages><style face="normal" font="default" size="100%">55-60</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	From stents and large-diameter vascular grafts, to mechanical heart valves and blood pumps, blood-contacting devices are enjoying significant clinical success owing to the application of systemic antiplatelet and anticoagulation therapies. On the contrary, research into material and device hemocompatibility aimed at alleviating the need for systemic therapies has suffered a decline. This research area is undergoing a renaissance fueled by recent fundamental insights into coagulation and inflammation that are offering new avenues of investigation, the growing recognition of the limitations facing existing therapeutic approaches, and the severity of the cardiovascular disorders epidemic. This Opinion article discusses clinical needs for hemocompatible materials and the emerging research directions for fulfilling those needs. Based on the 2017 BloodSurf conference that brought together clinicians, scientists, and engineers from academia, industry, and regulatory bodies, its purpose is to draw the attention of the wider clinical and scientific community to stimulate further growth. Statement of Significance: The article highlights recent fundamental insights into coagulation, inflammation, and blood-biomaterial interactions that are fueling a renaissance in the field of material hemocompatibility. It will be useful for clinicians, scientists, engineers, representatives of industry and regulatory bodies working on the problem of developing hemocompatible materials and devices for treating cardiovascular disorders.
&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Molladavoodi, S</style></author><author><style face="normal" font="default" size="100%">Robichaud, M</style></author><author><style face="normal" font="default" size="100%">Wulff, D</style></author><author><style face="normal" font="default" size="100%">Gorbet, M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Corneal epithelial cells exposed to shear stress show altered cytoskeleton and migratory behaviour</style></title><secondary-title><style face="normal" font="default" size="100%">PLOS ONE</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1371/journal.pone.0178981</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">12</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Cells that form the corneal epithelium, the outermost layer of the cornea, are exposed to shear stress through blinking during waking hours. In this in vitro study, the effect of fluid shear stress on human corneal epithelial cells (HCECs) was investigated. Following exposure to shear stresses of 4 and 8 dyn/cm2, HCECs showed cytoskeletal rearrangement with more prominent, organized and elongated filamentous actin. Cytoskeletal changes were time-dependent, and were most significant after 24 hours of shear stress. Higher rates of migration and proliferation, as evaluated by a scratch assay, were also observed following 24 hours of low shear stress exposure (4 dyn/cm2). This result contrasted the poor migration observed in samples scratched before shear exposure, indicating that shear-induced cytoskeletal changes played a key role in improved wound healing and must therefore precede any damage to the cell layer. HCEC cytoskeletal changes were accompanied by an upregulation in integrin β1 and downregulation of ICAM-1. These results demonstrate that HCECs respond favourably to flow-induced shear stress, impacting their proliferation and migration properties as well as phenotype.</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue></record></records></xml>