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Hopkins group advances our understanding of molecular clusters from fundamental insights to applications

Thursday, February 4, 2016

Journal covers

Four recent articles from the Hopkins group have been highlighted on journal covers. These publications all focus on determining the physicochemical properties of isolated clusters.

The Hopkins and McMahon labs collaborated to show that infrared excitation can be used to influence the fragmentation pathways of amino acid clusters in an isomer-specific and vibrational mode-selective manner. This suggests that it might be possible to use lasers to control amino acid chemistry. Their joint project was published in Physical Chemistry Chemical Physics, a journal of the Royal Society of Chemistry. 

The Hopkins group also collaborated with researchers from SCIEX and Pfizer to demonstrate that the clustering propensities of drug candidates as measured by differential mobility spectrometry (DMS) correlate with quantum chemical predictions from microsolvation studies. This suggests that DMS might be a viable new tool for drug discovery. Their work was published in Analyst, which is also a journal of the Royal Society of Chemistry.

The labs of Hopkins, Fillion and McMahon also investigated the structures and charge-transfer properties of transition metal B12F12 clusters. This work demonstrates that the charge-transfer properties and chemical reactivities of these species can be tuned via substitution of the transition metal. This work was published in the Journal of Physical Chemistry A.

The second paper in the Journal of Physical Chemistry A from the Hopkins lab discusses the structures and properties of rhodium sulphide clusters and provide some insight into the mechanism by which surface bound Sulphur poisons rhodium catalytic activity.