Learning the ABCs of physiologically based pharmacokinetics (PBPK)

Sunday, December 4, 2011

Physiologically based pharmacokinetics. While this may seem like the mother of all tongue twisters, it is actually at the heart of Andrea Edginton’s research at Waterloo’s School of Pharmacy.

Photo of Andrea Edginton

Physiologically based pharmacokinetics, also known as PBPK, uses mathematical modeling and simulation techniques to predict how to correctly dose pharmaceutical drugs for special populations such as children and patients with disease. Edginton’s research focuses on children in particular, and how differing physiology can affect the pharmacokinetics of drugs.

PBPK modeling allows us to create a virtual child to predict how a drug might behave,” says Edginton. “Children are so different from adults, not just in size but in organ physiology and most importantly, enzyme maturity. PBPK modeling can help us determine how to administer new drugs in children when we have no experience doing so.

Edginton hopes her research will lead to more optimal drug therapy.

My goal is to get the right dose in that unique patient the very first time.