Events

Monday, October 30, 2017

Monday, October 30, 2017 — 4:00 PM EDT

Analysis of Clinical Trials with Multiple Outcomes

In order to obtain better overall knowledge of a treatment effect, investigators in clinical trials often collect many medically related outcomes, which are commonly called as endpoints. It is fundamental to understand the objectives of a particular analysis before applying any adjustment for multiplicity. For example, multiplicity does not always lead to error rate inflation, or multiplicity may be introduced for purpose other than making an efficacy or safety claim such as in sensitivity assessments. Sometimes, the multiple endpoints in clinical trials can be hierarchically ordered and logically related. In this talk, we will discuss the methods to analyze multiple outcomes in clinical trials with different objectives:  all or none approach, global approach, composite endpoint, at-least-one approach.

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