Department seminar by Jinko Graham, Simon Fraser UniversityExport this event to calendar

Thursday, May 17, 2018 — 4:00 PM EDT

Combining phenotypes, genotypes and genealogies to find trait-influencing variants


A basic tenet of statistical genetics is that shared ancestry leads to trait similarities in individuals. Related individuals share segments of their genome, derived from a common ancestor. The coalescent is a popular mathematical model of the shared ancestry that represents the relationships amongst segments as a set of binary trees, or genealogies, along the genome.  While these genealogies cannot be observed directly, the genetic-marker data enable us to sample from their posterior distribution.  We may compare the clustering of trait values on each genealogical tree that is sampled to the clustering under the coalescent prior distribution. This comparison provides a latent p-value that reflects the degree of surprise about the trait clustering in the sampled tree.  The distribution of these latent p-values is the fuzzy p-value as defined by Geyer and Thompson. The fuzzy p-value contrasts the posterior and prior distributions of trait clustering on the latent genealogies and is informative for mapping trait-influencing variants. In this talk, I will discuss these ideas with application to data from an immune-marker study, present results from preliminary analyses and highlight potential avenues for further research.

Location 
M3 - Mathematics 3
Room: 3127
200 University Avenue West
Waterloo, ON N2L 3G1
Canada

S M T W T F S
29
30
31
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
1
  1. 2018 (29)
    1. September (1)
    2. August (3)
    3. July (2)
    4. June (1)
    5. May (4)
    6. April (2)
    7. March (4)
    8. February (2)
    9. January (10)
  2. 2017 (55)
    1. December (3)
    2. November (11)
    3. October (5)
    4. September (7)
    5. August (1)
    6. July (1)
    7. June (2)
    8. May (4)
    9. April (2)
    10. March (3)
    11. February (4)
    12. January (12)
  3. 2016 (44)
  4. 2015 (38)
  5. 2014 (44)
  6. 2013 (46)
  7. 2012 (44)