Department seminar by Louise Ryan, Joseph Jacobson, Sandra Jacobson, and Tugba Akkaya HocagilExport this event to calendar

Thursday, February 14, 2019 — 1:00 PM EST

* PLEASE NOTE: This seminar has been cancelled. 

Propensity scores and missing data, with application to research on effects of prenatal alcohol exposure 


We discuss challenges in analysing data from several epidemiological cohort studies designed to explore the association between prenatal alcohol exposure and child development. After Professors Sandra and Joseph Jacobson briefly describe the broader context, Professor Ryan will give a brief overview of the statistical challenges. Dr. Akkaya will then go into more detail, describing the approaches we have been taking, using propensity score analysis to adjust for potential confounders.  She will briefly review propensity score methods and their extension to application with continuous predictors, such as the amount of alcohol consumed by the mother during pregnancy.  She will then discuss extensions we have developed, using multiple imputation, to handle missing and misspecified covariates in this context.  In particular, she will describe a strategy for incorporating variables that have a two-part or semi-continuous structure.  This arises in our setting, for example, since many women will have zero exposure (meaning they are non-drinkers or abstainers), while there will then be a wide and long-tailed distribution of exposure levels among those who drink.   Two-part or semi-continuous variables also arise among the potential confounding variables in our study, for example, use of cocaine and other drugs during pregnancy.

Location 
M3 - Mathematics 3
Room: 3127
200 University Avenue West

Waterloo, ON N2L 3G1
Canada

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