BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Drupal iCal API//EN
X-WR-CALNAME:Events items teaser
X-WR-TIMEZONE:America/Toronto
BEGIN:VTIMEZONE
TZID:America/Toronto
X-LIC-LOCATION:America/Toronto
BEGIN:DAYLIGHT
TZNAME:EDT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
DTSTART:20190310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:EST
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
DTSTART:20191103T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:69f33465b58fd
DTSTART;TZID=America/Toronto:20200109T100000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20200109T100000
URL:https://uwaterloo.ca/statistics-and-actuarial-science/events/department
 -seminar-glen-mcgee-harvard-th-chan-school-public
LOCATION:M3 - Mathematics 3 200 University Avenue West Room 3127 Waterloo O
 N N2L 3G1 Canada
SUMMARY:Department seminar by Glen McGee\, Harvard T.H. Chan School of Publ
 ic\nHealth
CLASS:PUBLIC
DESCRIPTION:METHODOLOGICAL PROBLEMS IN MULTIGENERATIONAL EPIDEMIOLOGY\n\
 n-------------------------\n\nWhile epidemiology has typically focused on 
 how exposures impact the\nindividuals directly exposed\, recent interest h
 as been shown in\ninvestigating exposures with multigenerational effects
 —ones that\naffect the children and grandchildren of those directly expo
 sed. For\nexample\, a recent motivating study examined the association bet
 ween\nmaternal in-utero diethylstilbestrol exposure and ADHD in the Nurses
 \nHealth Study II. Such multigenerational studies\, however\, are\nsuscept
 ible to informative cluster size\, occurring when the number of\nchildren 
 to a mother (the cluster size) is related to their outcomes.\nBut what if 
 some women have no children at all? We first consider this\nproblem of inf
 ormatively empty clusters. Second\, observing populations\nacross multiple
  generations can be prohibitively expensive\, so\nmultigenerational studie
 s often measure exposures\nretrospectively—and hence are susceptible to 
 misclassification and\nrecall bias. We thus study the impact of exposure m
 isclassification\nwhen cluster size is potentially informative\, as well a
 s when\nmisclassification is differential by cluster size. Finally\, outsi
 de\nthe relative control of laboratory settings\, population-based\nmultig
 enerational studies have had to entertain a broad range of study\ndesigns.
  We show that these designs have important implications on the\nscope of s
 cientific inquiry\, and we highlight areas in need of further\nmethodologi
 cal research.
DTSTAMP:20260430T105221Z
END:VEVENT
END:VCALENDAR