Our People - Understanding Microbes

519-888-4567 x36084
Location: 
E6 4012 E6 4113

Expertise:

  • Complex biologics (products derived from living organisms or the organisms themselves)
  • Baculovirus expression systems of complex biologics, including glycosylation and myritoylation post-translational modifications
  • Cell culture monitoring, modeling and simulation – from metabolomics to on-line spectroscopy
  • Monoclonal antibody production and modification, including enhancing monodispersity of the product
     
Group(s): 
Operating Committee; Faculty→Engineering; Position→Faculty; Research Theme→Microbes and Technology, Understanding Microbes
519-888-4567 x36278
Location: 
DC 2516

Expertise:

  • Computational methods to analyze biological sequences, including design of algorithms for large-scale evolutionary tree reconstruction
  • Computational methods to correct DNA sequence reads
  • Bioinformatics problems including alignment, gene finding, haplotype inference, motif finding, HMM decoding, HIV subtype detection and kinship discovery
     
Group(s): 
Faculty→Mathematics; Position→Faculty; Research Theme→Understanding Microbes
519-888-4567 x33310
Location: 
E6 4004

Expertise:

  • Microbial production of recombinant proteins and therapeutic proteins including industrial enzymes and effective microbial host/vector systems
  • Microbial production of industrial useful metabolites including biohydrogen, biodiesel, and biobutanol
  • Bioprocess development including upstream technology for biological strain construction, midstream technology for bioreaction (e.g., cultivation), and downstream processing for bioproduct recovery and purification
  • Optimization of microbial production including: identification of expression limiting steps, protein secretion (i.e., periplasmic or extracellular expression), surface display, posttranslational issues, physiological manipulation of host strains, in-vivo protein misfolding (i.e., soluble expression), in-vitro protein refolding, fusion-protein technology, molecular manipulation of proteins, pathway knockouts, pathway constructions, etc.
     
Group(s): 
Faculty→Engineering; Position→Faculty; Research Theme→Microbes and Technology, Understanding Microbes
519-888-4567 x33889
Location: 
B1 166A

Expertise:

  • Bioinformatics, computational biology and molecular genetics
  • Predicting novel protein families and functions by combining sequence analysis with structural bioinformatics
  • Predicting evolutionary adaptations in genes and genome by combining sequence analysis, phylogenetics and structural modeling
  • Computational approaches to functionally annotate metagenomes and detect biologically relevant differences between them
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Understanding Microbes
519-888-4567 x33957
Location: 
B1 291B

Expertise:

  • DNA replication, cell cycle checkpoints, molecular genetics
  • Saccharomyces cerevisiae as a model organism for cancer-related studies of the cell cycle
  • Initiation of DNA replication including identifying and characterizing protein factors
  • Cancer diagnostic markers for cell proliferation
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Health, Understanding Microbes
519-888-4567 x35954
Location: 
ESC 233

Expertise:

  • Protein structure and function, enzymology, biophysics
  • Nitric oxide synthase including understanding the regulation and mechanism of this enzyme and its interactions with calmodulin
  • Class II aldolases in fungi and Mycobacterium tuberculosis as a drug target
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Health, Understanding Microbes
519-888-4567 x31559
Location: 
ESC 249 STC 4038

Expertise:

  • Enzyme structure, mechanism, inhibition and allostery
  • Role of conformational plasticity in enzyme function
  • Phosphoenolpyruvate carboxykinase enzyme
  • IgA1 proteases and their role in pathogenesis of mucosal infection
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Health, Understanding Microbes
519-888-4567 x35817
Location: 
ESC 246

Expertise:

  • Protein structure and function
  • Understanding of enzyme catalytic mechanisms including in methionine biochemistry and glyoxalase metalloenzymes
  • Bio-nanotechnology including nanosized proteins as drug carriers and molecular foundations for nanodevices
  • Bacteriophages to produce building blocks used in advanced biomaterials
  • Interactions between biomolecules and nanomaterials
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Technology, Understanding Microbes
519-888-4567 x31151
Location: 
B1 281

Expertise:

  • Microbial diversity and function, especially at contaminated sites (primarily municipal landfills)
  • Microbiome analysis (DNA, RNA and protein in metagenomics, metatranscriptomics and metaproteomics) from environmental samples
  • Bioremediation tool development from exploration of microbial community interactions

Publications:

Laura Hug's Publication list

Group(s): 
Operating Committee; Faculty→Science; Position→Faculty; Research Theme→Microbes and the Environment, Understanding Microbes
519-888-4567 x35457
Location: 
MC 6116

Expertise:

  • Applications of systems and control theory to systems biology
  • Design and construction of gene regulatory networks from forward-engineering of biological systems (synthetic biology)
  • Modelling intracellular networks and heterogeneous cellular communities
     
Group(s): 
Operating Committee; Faculty→Mathematics; Position→Faculty; Research Theme→Microbes and Technology, Understanding Microbes
519-888-4567 x33562
Location: 
B1 379C

Expertise:

  • Hyperthermophilic microorganisms growing at 80°C and above
  • Microbial physiology and enzymology
  • Alcohol and H2 fermentation using novel enzymes that work at high temperatures
  • Biocatalysis using thermostable enzymes for the production of chiral compounds
  • High temperature biochemistry and protein engineering
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Technology, Understanding Microbes
519-888-4567 x37020
Location: 
B1 165A

Expertise:

  • Proteomics analysis, that is, identifying and quantifying the proteins active within a biological system
  • Computational and bioinformatics approaches for investigating protein function
  • Quantification of cell cycle proteins in yeast, recombinant protein production in mammalian cell lines, and identification of proteins mediating plant-bacterial interactions
  • Structural pattern recognition algorithms to predict protein functions such as carbohydrate binding and antifreeze activity
  • Evolution of protein function within homologous protein groups
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Technology, Understanding Microbes
519-888-4567 x32224
Location: 
B2 245A

Expertise:

  • World expert on Bangiales – types of red algae
  • Red algae of economic importance - they contain compounds (agar, carrageenan, etc.) that are used extensively as thickeners in products such as yogurt, ice cream and toothpaste
  • Red algae as food sources - genera such as Porphyra (aka. Nori, laverbread) and Palmaria (a.k.a. Dulse) are important food sources and are global billion-dollar aquaculture industries
  • Red algae as a critical group in the evolution of photosynthetic life on earth through secondary endosymbiosis of chloroplasts
  • Red algae as a nuisance - (e.g. Cladophora and Chara in Laurentian Great Lakes), invasive species (e.g. Bangia atropupurea in the Great Lakes)
  • Cyanobacteria that release toxins and taste and odour compounds in drinking water (Lake Ontario)
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and the Environment, Understanding Microbes
519-888-4567 x38344
Location: 
B1 275, B1 294, B1 289

Expertise:

  • Microbial diversity - developing and applying molecular and computational methods to explore complex microbial communities spanning aquatic, terrestrial, and host-associated habitats
  • Linking function and phylogeny - by exploring active microorganisms involved in transforming carbon and energy, to better understand who is doing what in the environment
  • Nitrogen cycle - using a combination of molecular and cultivation approaches to investigate the microbial community members associated with ammonia oxidation and denitrification

Publications:

Josh Neufeld's Publication List

Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and the Environment, Understanding Microbes
519-888-4567 x35100
Location: 
ESC 234 ESC 241

Expertise:

  • Protein-lipid interaction in biological membranes
  • Bacterial pore-forming toxins – structure and function
  • Lipopeptide antibiotics – structure and function
  • Fluorescence methods to study protein-protein and protein-membrane interactions
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Health, Understanding Microbes
519-888-4567 x30509
Location: 
ESC 244 STC 4042

Expertise:

  • Enzymes that recognize and act upon carbohydrates, including especially glycosidases involved in the protein glycosylation pathway and the process of starch digestion
  • Starch breakdown in mammalian cells (e.g. treatment of Type II Diabetes)
  • Human gut commensal microbial species – starch digestion enzymes
     
Group(s): 
Faculty→Science; Position→Faculty; Research Theme→Microbes and Health, Understanding Microbes
519-888-4567 x35454
Location: 
MC 6114

Expertise:

  • Determining ‘growth laws’ of bacteria through an understanding of genetic networks using mathematical physics and experimental microbiology
Group(s): 
Faculty→Mathematics; Position→Faculty; Research Theme→Understanding Microbes