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UID:6a2aa70826080
DTSTART;TZID=America/Toronto:20260707T133000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20260707T143000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-res
 earch-talk-prof-david-stuart-university-alberta
SUMMARY:WCMR Research Talk: Prof. David Stuart\, University of Alberta
CLASS:PUBLIC
DESCRIPTION:Tuesday July 7\, 2026\n\n1:30 pm\n\nDC 1302\n\n\"ENGINEERING MI
 CROBIAL CELLS FOR APPLICATION AS LIVE CELL\nTHERAPEUTICS\"\n\nThe ominous 
 rise in the frequency of antibiotic resistant microbial\ninfections poses 
 a global threat to human health. This threat comes in\nthe direct form of 
 disease related to infection of humans but also\nindirectly in the form of
  challenges to food security through loss of\nagricultural crops and anima
 ls to disease. The development of\nantibiotic drugs in previous decades w
 as transformational\, providing\ncheap\, effective treatment for what woul
 d otherwise would be a lethal\ninfection. As microbial strains resistant t
 o our front-line antibiotic\ndrugs have emerged\, there is an urgent need
  to develop new\ntherapeutic strategies and tools. Synthetic biology a
 nd metabolic\nengineering can be applied to generate \"weaponized\" live c
 ell\ntherapeutics providing new means to combat the rapidly evolving threa
 t\nof microbial pathogens. In this presentation\, I will highlight\nprogre
 ss from my laboratory in engineering probiotic microbial cells\nthat have 
 been endowed with functionalities derived from\nbacteriophages and synthet
 ic nanobodies allowing them to inhibit\nmicrobial toxins\, kill microbial 
 pathogens and deliver therapeutic\nmolecules. The potential benefits of en
 gineered probiotics are\nhighlighted along with the challenges that must s
 till be met before\nthese intriguing new therapeutic tools can be widely d
 eployed.
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa70828dc6
DTSTART;TZID=America/Toronto:20260123T113000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20260123T130000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-win
 ter-2026-open-house
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Room DC 1301 Waterloo ON N2L 3G1 Canada
SUMMARY:WCMR Winter 2026 Open House
CLASS:PUBLIC
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082a10f
DTSTART;TZID=America/Toronto:20251003T120000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20251003T130000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-fal
 l-2025-open-house
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Room DC 1301 Waterloo ON N2L 3G1 Canada
SUMMARY:WCMR Fall 2025 Open House
CLASS:PUBLIC
DESCRIPTION:Fall 2025 WCMR Open House
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082ad2a
DTSTART;TZID=America/Toronto:20260707T130000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20260707T170000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/2nd-annu
 al-wcmr-research-symposium
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Waterloo ON N2L 3G1 Canada
SUMMARY:2nd Annual WCMR Research Symposium
CLASS:PUBLIC
DESCRIPTION:The 2026 WCMR Research Symposium event will take place on July 
 7.  
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082b882
DTSTART;TZID=America/Toronto:20250516T120000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20250516T130000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-spr
 ing-2025-open-house
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Room DC 1301 Waterloo ON N2L 3G1 Canada
SUMMARY:WCMR Spring 2025 Open House
CLASS:PUBLIC
DESCRIPTION:Spring 2025 WCMR Open House
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082c335
DTSTART;TZID=America/Toronto:20250214T123000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20250214T140000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-win
 ter-welcome-2025
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Room DC 1301 Waterloo ON N2L 3G1 Canada
SUMMARY:WCMR Winter Welcome 2025
CLASS:PUBLIC
DESCRIPTION:Event page for Winter 2025 WCMR Open House
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082ce02
DTSTART;TZID=America/Toronto:20241004T120000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20241004T130000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-fal
 l-2024-open-house
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Room DC 1301 Waterloo ON N2L 3G1 Canada
SUMMARY:WCMR Fall 2024 Open House
CLASS:PUBLIC
DESCRIPTION:Event page for Fall 2024 WCMR Open House
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082d8a8
DTSTART;TZID=America/Toronto:20241022T150000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20241022T163000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/2024-gai
 rdner-national-lecture-dr-christian-landry
LOCATION:EV3 - Environment 3 Room 4412 200 University Avenue West Waterloo 
 ON N2L 3G1 Canada
SUMMARY:2024 Gairdner National Lecture: Dr. Christian Landry
CLASS:PUBLIC
DESCRIPTION:The 2024 Gairdner National Lecture with Dr. Christian Landry: T
 owards\na Complete Understanding of Drug Resistance in Pathogenic Fungi
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082e73e
DTSTART;TZID=America/Toronto:20240628T120000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20240628T130000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-spr
 ingsummer-2024-open-house
LOCATION:DC - William G. Davis Computer Research Centre 200 University Aven
 ue West Room DC 1301 Waterloo ON N2L 3G1 Canada
SUMMARY:WCMR Spring/Summer 2024 Open House
CLASS:PUBLIC
DESCRIPTION:Event page for S2024 WCMR Open House
DTSTAMP:20260611T121608Z
END:VEVENT
BEGIN:VEVENT
UID:6a2aa7082f497
DTSTART;TZID=America/Toronto:20240423T130000
SEQUENCE:0
TRANSP:TRANSPARENT
DTEND;TZID=America/Toronto:20240423T143000
URL:https://uwaterloo.ca/waterloo-centre-microbial-research/events/wcmr-mon
 thly-meetup-2
LOCATION:Universtity of Waterloo 200 University Avenue West B1-266 Waterloo
  ON N2L 3G1 Canada
SUMMARY:WCMR Monthly Meetup
CLASS:PUBLIC
DESCRIPTION:> SHIRLEY WONG\, POSTDOCTORAL FELLOW PRESENTS:\n> \n> TO
 WARDS VALORIZATION OF FOOD WASTE TO BIOPLASTIC IN _PSEUDOMONAS\n>
  ALLOPUTIDA_ \n> \n> ABSTRACT: \n> \n> Annually\, over a billion
  tonnes of food is wasted\, where it largely\n> ends up in lan
 dfills and massively contributes to the emission of\n> greenhouse
  gases. To improve global sustainability\, this low-value\n> carbo
 n resource can instead be converted into high-value bio-based\n> 
 products. Microbial valorization of food waste has been validated\
 n> for many applications\, from biofuels to bioplastic polymers l
 ike\n> polyhydroxyalkanoates (PHAs). Much effort has gone into pro
 cessing\n> heterogenous food waste towards such applications\, such
  as anaerobic\n> digestion to produce short-chain fatty acids (sc
 FAs)\, a group of\n> industrially-relevant fatty acids that can b
 e used as building\n> blocks for other bioproducts. _Pseudomonas 
 alloputida_ is a highly\n> promising PHA producer but its ability
  to metabolize scFAs is\n> limited.\n> \n> To improve the capaci
 ty of PH production on scFAs and\, therefore\,\n> enable its upc
 ycling of food waste into high-value bioplastic\, we\n> are using
  functional metagenomics to mine exogenous carbon\n> utilization p
 athways from the environment. Environmental microbial\n> communities
  represent rich\, untapped reservoirs of novel genes and\n> metab
 olic pathways. Here\, we present community analyses of compost\n>
  and soil microbiomes enriched for utilization of short (C2-C5)\n
 > versus medium chain fatty acids (C8 and C9) under conditions\n
 > conducive to PHA accumulation. We are furthermore constructing\n
 > metagenomic libraries from the enriched cultures using the\n> b
 road-host-range cosmid pJC8\, with an average insert size of 33 
 kb.\n> The metagenomic libraries will enable us to functionally s
 creen for\,\n> identify\, and isolate exogenous metabolic pathways
  that could\n> support scFA-PHA conversion by _P. alloputida_. Ad
 ditionally\, we\n> further characterize the ability of engineered 
 _P. alloputida_ to\n> use VFAs in bioplastic production\, demonstr
 ating its use in food\n> waste valorization.
DTSTAMP:20260611T121608Z
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