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DTSTART:20260308T070000
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DTSTART:20251102T060000
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DTSTART;TZID=America/Toronto:20261001T110000
SEQUENCE:0
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DTEND;TZID=America/Toronto:20261001T120000
URL:https://uwaterloo.ca/waterloo-eye-institute-vision-science-consortium/e
 vents/seminar-biology-nicole-noel
LOCATION:B1 - Biology 1 room 370 Waterloo ON N2L 3G1 Canada
SUMMARY:Seminar in Biology by Nicole Noel
CLASS:PUBLIC
DESCRIPTION: INVESTIGATING PHOTORECEPTOR SPECIALISATIONS AND BREAKDOWN THR
 OUGH\nFISH MODELS\n\nAbstract: Vision is dependent on the appropriate deve
 lopment\,\narrangement\, and maintenance of the light-detecting photorecep
 tor\ncells. Despite decades of study\, it is still unclear how distinct\np
 hotoreceptor organisations (termed mosaics) impact vision in diverse\nfish
  species. Photoreceptor proportion and mosaic organisation\ninfluences dis
 ease manifestation\, but the mechanisms that underlie the\nassociation bet
 ween photoreceptor mosaic structure and age-related\ndegradation are ambig
 uous. The turquoise killifish (N. furzeri) is an\nemerging model of accele
 rated ageing which can be utilised to\ninvestigate how photoreceptor speci
 alisations contribute to visual\nfunction across species and also assess a
 ge-related deterioration. I\ndetermined that the turquoise killifish has p
 hotoreceptor proportions\nakin to the human central retina\, and distinct 
 photoreceptor topology\ncompared to the commonly used zebrafish model. I a
 lso observed that\nturquoise killifish develop many of the hallmark age-re
 lated retinal\npresentations seen in humans\; thus\, they serve as a natur
 ally\noccurring model of ageing retinal disease that can be used to\ndeter
 mine why photoreceptors break down over time. My work will\ninvestigate ho
 w vision differs between fish species as a consequence\nof their respectiv
 e photoreceptor mosaics\, as well as identify\npathomechanisms underlying 
 age-related photoreceptor deterioration. 
DTSTAMP:20261006T164810Z
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