“My overarching research goal is to develop practical and effective solutions that identify those with deleterious changes in body composition (loss of muscle, gains in adipose tissue) and design strategies that manage or improve skeletal muscle health.”
Topics of Interest
| Cancer | Our current work is focused in understanding the changes in body composition that occur in breast and prostate cancer patients. We are also investigating nutrition and exercise interventions. |
|---|---|
| Metabolic Conditions (i.e. Diabetes, Liver, and Kidney Disease) | Our current work is focused on understanding body composition phenotypes in relation to metabolic profiles in people diagnosed with diabetes, liver, and kidney diseases. |
| Ultrasound | Our current work is focused on characterizing muscle and adipose tissue characteristics at various anatomical sites, and the metabolic implications of these characteristics. |
| Body Composition Methods | Our current work is focused on developing new approaches to understanding body composition profiles, including muscle atrophy and overweight/obesity, and their effects on health. |
| Muscle Atrophy | Our current work examines how loss of muscle affects health outcomes. |
Populations of Interest
Young and older healthy populations.
Populations demonstrating loss of muscle mass, including; cancer, critically ill, liver cirrhosis, kidney disease, diabetes.
Selected Publications
* indicates IMBC lab members or alumni
> indicates shared first authorship
Furberg H, Bradshaw P, Knezevic A, Olsson L, Petruzella S, Stein E, Paris M, Scott J, Akin O, Hakimi AA, Russo P, Caan B and Mourtzakis M. The Resolve Study: Evaluating the clinical relevance of body composition at time of diagnosis among non-metastatic clear cell renal cell cancer patients (ccRCC). Journal of Cachexia, Sarcopenia and Muscle 15(2):726-734, 2024.
Bell KE*, Paris MT*, Avrutin E*, Mourtzakis M. Altered features of body composition in older adults with type 2 diabetes and prediabetes compared with matched controls. Journal of Cachexia, Sarcopenia and Muscle. 13(2):1087-1099, 2022.
Paris M*, Bell K*, Avrutin E*, Mourtzakis M. Association of strength, power, and physical performance with muscle mass and composition in older males: a comparison of muscle thickness, echo intensity, and lean tissue mass. Applied Physiology, Nutrition and Metabolism 47(5):521-528, 2022.
Paris MT*, Bell KE*, Avrutin E*, Mourtzakis M. Body size normalization of ultrasound measured anterior upper leg muscle thickness in younger and older males and females. European Journal of Clinical Nutrition. 76(7):958-963, 2022.
Paris M*, Bell K*, Avrutin E*, Rosati K* and Mourtzakis M. Influence of subcutaneous adipose tissue and skeletal muscle thickness on rectus femoris echo intensity in younger and older males and females. Journal of Ultrasound in Medicine. 41(9):2355-2364, 2022.
Barazzoni R, Jensen GL, Correia ITD, Gonzalez MC, Higashiguchi T, Shi HP, Bischoff SC, Boirie Y, Carrasco F, Cruz-Jentoft A, Fuchs-Tarlovsky V, Fukushima R, Heymsfield S, Mourtzakis M, Muscaritoli M, Norman K, Nyulasi I, Pisprasert V, Prado C, de van der Schuren M, Yoshida S, Yu Y, Cederholm T, Compher C. Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition. Clinical Nutrition 41(6): 1425-1433, 2022.
Kelly CR*, Mourtzakis M, Furberg H, Tandon P, Paris MT*. Rectus abdominis muscle thickness is a valid measure of cross-sectional area: implications for ultrasound. Academic Radiology. 29(3): 382-387, 2022.
Compher C, Cederholm T, Correia MITD, Gonzalez MC, Higashiguchi T, Shi HP, Bischoff SC, Boirie Y, Carrasco F, Cruz-Jentoft A, Fuchs-Tarlovsky V, Fukushima R, Heymsfield S, Mourtzakis M, Muscaritoli M, Norman K, Nyulasi I, Pisprasert V, Prado C, de van der Schuren M, Yoshida S, Yu Y, Jensen G, Barazzoni R. Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition. Journal of Parenteral and Enteral Nutrition. 46(6): 1232-1242, 2022.
Paris MT*, Bell KE*, Avrutin E*, Mourtzakis M. Older males exhibit reduced anterior upper leg and anterior abdominal muscle thickness compared to younger males when matched for relative appendicular lean tissue. Archives of Gerontology and Geriatrics. 96:104483, 2021.
Bell KE*, Pfeiffer AG*, Schmidt S*, Bos L*, Russell C, Barnes T*, Avrutin E*, Gibson M*, Dubin JA, Mourtzakis M. Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer. Scientific Reports.11(1):22758, 2021.
Paris MT* and Mourtzakis M. Muscle composition analysis of ultrasound images: a review of texture analysis. Ultrasound in Medicine and Biology. 47(4):880-895, 2021.
Moisey LL*, Pikul J, Keller H, Yeung CY, Rahman A, Heyland DK, Mourtzakis M. Adequacy of protein and energy intake in critically ill adults following liberation from mechanical ventilation is dependent on route of nutrition delivery. Nutrition in Clinical Practice. 36(1):201-212, 2021.
Paris MT*, Letofsky N*, Mourtzakis M. Site-specific skeletal muscle quantity and composition differences in subcutaneous adipose tissue matched older and younger adults. Clinical Physiology and Functional Imaging. 41(2):156-164, 2021.
Bell KE*, Schmidt S*, Pfeiffer A*, Bos L*, Earthman C, Russell C, Mourtzakis M. Bioelectrical impedance analysis overestimates fat-free mass in breast cancer patients undergoing treatment. Nutrition in Clinical Practice. 35(6):1029-1040, 2020.
Paris MT*, Tandon P, Heyland DK, Furberg H, Premji T*, Mourtzakis M. Automated body composition analysis of clinically acquired computed tomography scans using neural networks. Clinical Nutrition. 39(10):3049-3055, 2020.
Paris MT*, Bell KE*, Mourtzakis M. Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise. Invited Review. Current Opinion in Pharmacology. 52:61-66, 2020
Barnes T*, DiSebastiano K*, Vlavcheski F, Quadrilatero J, Tsiani EL, Mourtzakis M. Glutamate increases glucose uptake in L6 myotubes in a concentration- and time-dependant manner that is mediated by AMPK. Applied Physiology Nutrition and Metabolism. 43(12):1307-1313, 2018.
Parry SM, Chapple LS, Mourtzakis M. Exploring the potential effectiveness of combining optimal nutrition with electrical stimulation to maintain muscle health in critical illness: A narrative review. Nutrition in Clinical Practice. 33(6):772-789, 2018.
Paris MT*, Mourtzakis M. Development of a bedside applicable ultrasound protocol to quantify fat mass index derived from whole body dual-energy x-ray absorptiometry scans. Nutrition. 57:225-230, 2018.
Avrutin E*, Moisey L*, Zhang R*, Khattab J*, Todd E*, Premji T*, Kozar R, Heyland DK, Mourtzakis M. Clinically practical approach for screening of low muscularity using electronic linear measures on computed tomography (CT) images in critically ill patients. J Parenteral Enteral Nutrition. 42(5):885-891, 2018.
DiSebastiano KM*, Bell KE*, Mitchell AS, Quadrilatero J, Dubin JA, Mourtzakis M. Glucose metabolism during the acute prostate cancer treatment trajectory: The Influence of Age and Obesity. Clinical Nutrition. 37(1):195-203, 2018.
Chan KS>, Mourtzakis M>, Friedman LA, Dinglas VD, Hough CL, Ely EW, Morris PE, Hopkins RO, Needham DM. Evaluating muscle mass in survivors of ARDS: A 1-year multi-center longitudinal study. Critical Care Medicine.46(8):1238-1246, 2018.
Mourtzakis M, Parry SM, Connolly B, Puthucheary Z. Skeletal muscle ultrasound in critical care: a tool in need of translation. Annals of American Thoracic Society. 14(10):1495-1503, 2017.
Paris M*, LaFleur B, Dubin J, Mourtzakis M. Development of a bedside viable ultrasound protocol to quantify appendicular lean tissue in a heterogeneous cohort of adults. Journal of Cachexia, Sarcopenia and Muscle. 8(5):713-726, 2017.
Paris M*, Mourtzakis M, Day A, Leung R, Watharkar S*, Kozar R, Earthman C, Kuchnia A, Dhaliwal R, Moisey L*, Compher C, Martin N, Nicolo M, White T, Roosevelt H, Peterson S, Heyland DK. VALIDation of bedside Ultrasound of Muscle layer thickness of the quadriceps in the critically ill patient (VALIDUM study): A prospective multicenter study. Journal of Parenteral and Enteral Nutrition. 41(2):171-180, 2017.
DiSebastiano KM*, Pinthus JH, Duivenvoorden WCM, Patterson L, Dubin JA, Mourtzakis M. Elevated C-peptides, abdominal obesity, and abnormal adipokine profile are associated with higher Gleason Scores in prostate cancer. The Prostate. 77(2):211-221, 2017.