Dr. Edginton’s research focuses on improving the confidence of physiologically-based pharmacokinetic (PBPK) model outcomes through understanding model inputs and developing modeling workflows.
Specifically, her research examines how the physiology of sub-populations, particularly children, affects the pharmacokinetics of drugs and how this information can be integrated into PBPK models for the optimization of drug therapy. Her PhD is from the University of Guelph in environmental toxicology where she examined the toxicokinetics of forestry-used herbicides on amphibians. A post-doctoral position followed in the Systems Biology group at Bayer Technology Services (BTS) in Leverkusen, Germany where physiologically-based pharmacokinetic modeling was the focus. A full-time position at BTS followed the post-doc for 2 years and then, coming back home to Waterloo, Ontario, Canada, she became an Assistant Professor in 2008 and an Associate Professor in 2014 at the University of Waterloo. Dr. Edginton spearheads the pharmacokinetic educational requirements for both the undergraduate and graduate programs.
This research lab is also the population pharmacokinetic modelling lead within the Web-Accessible Population Pharmacokinetics Service – Hemophilia (WAPPS-Hemo.org) program. This program, initiated out of McMaster University by Dr. Alfonso Iorio, provides hemophilia treaters with a platform that, when given patient covariates and factor concentrate plasma levels, uses previously developed brand-specific population PK model and Bayesian forecasting to generate estimates of patient PK that can be used to optimize dosing in the individual. We have over 550 clinical sites using the WAPPS-Hemo service from over 50 countries.
Courses:
- Advanced Pharmacokinetics
- Pharmacokinetic Fundamentals
- Clinical Pharmacokinetics Instructor - throughout Integrated Patient Focused Care courses 2 through 9
Professional Appointments
2021 - present
Hallman Director & Professor, School of Pharmacy, University of Waterloo
2018 - 2020
Associate Director, Graduate Studies and Research, School of Pharmacy, University of Waterloo
2015-2018
Program Assessment Officer, School of Pharmacy, University of Waterloo
2014 - 2020
Associate Professor, School of Pharmacy, University of Waterloo
2013 - 2019
Chair, Clinical Research Ethics Board, University of Waterloo
2009 - present
Cross-appointed Faculty, Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
2012 – present
Special Graduate Faculty, Bioinformatics, University of Guelph, Guelph, Ontario, Canada
2013 - present
Special Graduate Faculty, Department of Pharmaceutical Sciences, University of Tennessee College of Pharmacy, Tennessee, USA
2008 - 2014
Assistant Professor, School of Pharmacy, University of Waterloo
Education & Relevant Work Experience
2015-2016
Fellow: Cohort 12, Academic Leadership Fellows Program (ALFP), American Association of Colleges of Pharmacy (AACP)
2006-2008
PBPK Scientist: Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany
2004-2006
Post-doctoral Fellow: Systems Biology, Bayer Technology Services GmbH, Leverkusen, Germany, NSERC PDF
1999-2004
Ph.D.: Environmental Toxicology, Department of Environmental Biology, University of Guelph, Guelph, ON, Canada
1994-1998
B.Sc.: Department of Environmental Biology, University of Guelph, Guelph, ON, Canada