PhD Student
Yicui is a PhD student specializing in Physiologically Based Pharmacokinetic (PBPK) modeling, using PK-Sim, MoBi, R, and Python. During her Master’s, Yicui developed pediatric PBPK models for heart failure drugs (e.g., digoxin, milrinone, levosimendan), incorporating age-specific physiology and pathophysiological characteristics of pediatric patients using -Sim. Yicui additionally built a CYP3A4-based drug-drug interaction (DDI) model and performed interspecies scaling to predict first-in-human doses for new drug candidates before clinical development, in collaboration with industry.