ðŠðĩðŪð ðķðģ ððžð ð°ðžððđðą ðąðēððēð°ð ðŪ ðð―ðēð°ðķðģðķð° ððĄð ððēðūððēðŧð°ðē ð·ððð ðŊð ððŋðŪð°ðļðķðŧðī ðķðžðŧ ðģðđðžð ððĩðŋðžððīðĩ ðŪ ð°ðĩðŪðŧðŧðēðđ ðŪ ðģðēð ðŧðŪðŧðžðšðēððēðŋð ððķðąðē?
In our newly published work in Talanta, we explored this using horizontally aligned multi-walled carbon nanotube (MWCNT) nanochannels. The nanotube channel was functionalized with DNA so that when the complementary target DNA binds at the channel entrance, it changes the local ionic environment and produces a measurable change in electrical resistance. What makes this interesting is the possibility of turning a molecular recognition event, something happening at the nanoscale into a directly measurable electrical signal.
In our experiments, the sensor showed a concentration-dependent response to complementary DNA, with a linear response between 2 and 20 ΞM. This work is one step toward developing simpler, label-free nanofluidic biosensing platforms for nucleic-acid detection.
Title: ððððĨðððĨð ððððŦðĒððððĒðĻð§ ðð§ð ðĶðððĄðð§ðĒðŽððĒð ðŪð§ðððŦðŽððð§ððĒð§ð ðĻð ðĄðĻðŦðĒðģðĻð§ðððĨðĨðē ððĨðĒð ð§ðð ððððð ð§ðð§ðĻððĄðð§ð§ððĨ ðððŊðĒðððŽ ððĻðŦ ðĒðĻð§ðĒð ððŪðŦðŦðð§ð-ðððŽðð ððð ððĒðĻðŽðð§ðŽðĒð§ð
Link: https://www.sciencedirect.com/science/article/pii/S0039914026011616
ðūðĪðĢðð§ððĐðŠðĄððĐððĪðĢðĻ ðĐðĪ Ethan Piercey and ððĄðĄ ðĐðð ððĪ-ððŠðĐððĪð§ðĻ ððĢð ððĪðĄðĄðððĪð§ððĐðĪð§ðĻ ðŽððĪ ððĪðĢðĐð§ðððŠðĐðð ðĐðĪ ðĐðððĻ ðŽðĪð§ð
