Pharmacokinetics is the quantitative assessment of what the body does to a chemical following exposure. The fate of a chemical in a living organism is a function of its physical-chemical properties as well as the anatomy and physiology of the organism. Four main concepts form the basis for describing the rate and extent of exposure. These are Absorption, Distribution, Metabolism and Excretion, or ADME for short.
Our research is focused on building virtual organisms to study the pharmacokinetics of drugs and environmental contaminants. Physiologically-based pharmacokinetic (PBPK) models provide a mechanistic means of understanding how changes in anatomy and physiology can affect the ADME of a chemical. PBPK models are predictive and can be used to scale pharmacokinetics across species (e.g., rat to human) and within a species (e.g., healthy adult humans to children or patients) with an eye towards determining the right dose (in medicine) or determining differential risks associated with contaminant exposure (in human health risk assessment).
This research lab is also the population pharmacokinetic modelling lead within the Web-Accessible Population Pharmacokinetics Service – Hemophilia (WAPPS-Hemo.org) program. This program, initiated out of McMaster University by Dr. Alfonso Iorio, provides hemophilia treaters with a platform that, when given patient covariates and factor concentrate plasma levels, uses previously developed brand-specific population PK model and Bayesian forecasting to generate estimates of patient PK that can be used to optimize dosing in the individual. We have 500+ clinical sites using the WAPPS-Hemo service from 40+ countries.
This website will provide you with further details of our current and future pharmacokinetic research. Peruse the list of publications and courses that I teach and email me if you have questions about the research or the website.
Students interested in graduate studies at either the M.Sc. or Ph.D. level with interests or experience in the following areas:
- PBPK modeling
- Pediatric PBPK modeling
- PK/PD modeling
can email me directly: aedginto@uwaterloo.ca
I am particularly interested in students who possess strong mathematical and/or statistical skills.
Meet our people
Dr. Andrea Edginton
Dr. Edginton’s research focuses on improving the confidence of physiologically-based pharmacokinetic (PBPK) model outcomes through understanding model inputs and developing modeling workflows.
News
Congratulations to Min-Soo Kim
Congratulations to Min-Soo Kim!
We are delighted to announce that Min-Soo Kim has been awarded the prestigious Korean Postdoctoral Scholarship for Postdoctoral Training Abroad (박사후국외연수). This highly competitive scholarship recognizes exceptional research potential and provides support for further training and research endeavors abroad.
Min-Soo Kim's selection as a successful applicant is a testament to their outstanding academic achievements and dedication to advancing knowledge in their field. This scholarship will provide invaluable opportunities for collaboration and professional growth on an international scale.
Please join us in congratulating Min-Soo Kim on this significant accomplishment and wishing them continued success in their postdoctoral journey.
Dr. Cindy Yeung Awarded 2024 CIHR Banting Postdoctoral Research Award
Congratulations to Dr. Cindy Yeung. She is one of 23 CIHR Banting Postdoctoral Fellowship recipients this year!
| Yeung, Cindy Hoi Ting | Hospital for Sick Children | Drug Research | Advancing towards model-informed precision dosing: Ontogeny and pharmacogenetics of commonly used drugs in the Neonatal Intensive Care Unit |
Congratulations Shirley!
Congratulations Shirley for winning Best Presentation at Pharmacy Research Day (University of Waterloo) "Physiologically-Based Pharmacokinetic Modelling of Sodium Benzoate in the Pediatric Population".