Shuji Chang

I got my BSc degree in Molecular Biology & Biotechnology from University of Liverpool and Xi’an Jiao Tong Liverpool University. I had my MRes degree in System & Synthetic Biology from Imperial College London. After graduation, I was working in the RD department of the Biopharmaceutic industry in China. Then I came to PhD project in Process System Engineering at the University of Waterloo with the supervision of Professor Hector Budman and Professor Luis Ricardez-Sandoval.

My research focuses on model-based optimization of scale-up/down operations in the biopharmaceutic industry. We are using CFD (computational fluid dynamics) techniques to simulate the flow pattern, local gradient, shear-sensitive zone, and biokinetics in small- and large-scale bioreactors. Meanwhile, we are developing a predictive model based on actual experimental data. AI algorithm, PINN (Physical-Informed Neuro Network), is our later objective for a surrogate model in parameter optimization and Advanced Process Control of bioreactor.