Novel enzymes in cardiolipin metabolism
We have found a role for PLAAT1 in cardiolipin metabolism and are investigating the function of this enzyme in various tissues in the body, using knockout mice that we have generated.
We are also studying the enzyme Tafazzin, which remodels cardiolipin, and causes Barth Syndrome when mutated in humans. Barth syndrome results in cardiomyopathy, immune deficiencies, fatigue, and other symptoms, and can significantly affect morbidity and mortality in those affected.
Nutraceuticals & bioactive lipids
We are studying roles for cannabinoids in viral infection and in other acute and chronic health conditions.
We are also studying effects of the mushroom psychotropic psilocybin on obesity and related chronic disease conditions.