- Spafford, J.D. et al. (+30 coapplicants) Upgrade of U of Waterloo's primary confocal microscope with state-of-the-art correlative microscopy (National Science and Engineering Research Council of Canada, Research Tools and Instrumentation Grant 2014)
- Spafford, J.D. Discovery of a cysteine scaffold serving as an ion selectivity filter and toxin/drug shield in T-type channels. (University of Waterloo Canadian Institute of Health Research Incentive Fund 2014)
- Spafford, J.D. et al. (+21 coapplicants) Basic confocal microscope needed for 37 users in the Faculties of Science and Engineering at the University of Waterloo(National Science and Engineering Research Council of Canada, Research Tools and Instrumentation Grant 2011)
- Spafford, J.D. et al. Analysis of a unique cation channel (LNALCN) that can be either a calcium channel or a sodium channel (National Science and Egineering Research Council of Canada Discovery Grant 2011-2016)
- Spafford, J.D. et al. (+2 coapplicants) Microelectrode puller requested for electrophysiologists at the University of Waterloo (National Science and Engineering Research Council of Canada, Research Tools and Instrumentation Grant 2011)
- Spafford, J.D. and coapplicant Honek, J.F. Structure-function analyses of drug interactions with L-type calcium channels (Heart and Stroke Foundation of Canada, Grant-in-Aid 2011-2013)
- Spafford, J. D. et al. (+12 coapplicants) Optical sectioning microscopy upgrades for muti-user core facility (National Science and Engineering Research Council of Canada, Research Tools and Instrumentation Grant 2009)
- Spafford, J. D. and coapplicant Honek J.F. Structure-function analyses of drug interactions with L-type calcium channels (Heart and Stroke Foundation of Canada, Grand-in-Aid 2008-2010)
- Spafford, J.D. et al. (+14 coapplicants) Digital Imaging Capability for NSERC Sponsored Multi-User Core Microscope Facility (National Science and Engineering Research Council of Canada, Research Tools and Instrumentation Grant 2007)
- Spafford, J. D. Cellular and molecular mechanisms underlying the targeting and localization of synaptic calcium channels (University of Waterloo Canadian Institute of Health Research Incentive Fund)
- Spafford, J. D. State of the Art Facility for the Development of New Biopharmaceuticals and Biomarkers (Government of Ontario, Ontario Research Fund 2007)
- Spafford, J. D. State of the Art Facility for the Development of New Biopharmaceuticals and Biomarkers (Canadian Foundation for Innovation Leaders Opportunity Fund 2006)
- Spafford, J. D. Structure and function of L-type calcium channels in Lymnaea stagnalis (National Science and Engineering Research Council of Canada Discovery Grant 2006-2010)
- Spafford, J. D. Recording Instrument for Electrophysiology (National Science and Engineering Research Council of Canada, Research Tools and Instrumentation Grant 2006)