About the Foldvari Group

The Foldvari Group is investigating novel materials, methods, mechanisms and pathways to enable the discovery and invention of needle-free administration of medicines. We are working on developing non-invasive drug delivery technologies and pharmaceutical products based on these technologies.

Our objectives are to:

  • Develop novel delivery systems and formulations for drugs, proteins, nucleic acids and vaccines
  • Create hybrid systems, e.g., DNA-nanoparticles, carbon nanotube composites and other unique structures
  • Create nanoprobe systems for diagnostics and repair of biological functions
  • Investigate natural and synthetic materials for fabrication of delivery and diagnostic systems
  • Create interfacing methods between physical and biological systems
  • Investigate molecular functions at the bio/nano interface using computer modelling and visualization of the delivery systems

The research themes in our laboratory include:

1. Nanomedicine Fundamental Studies

  • Protein and non-viral gene delivery mechanisms
  • Dermal, transdermal, ocular and mucosal (intranasal, buccal, vaginal) delivery routes
  • Nanomaterials in delivery system design
  • Nanosystem characterization and imaging
  • Mathematical modeling of absorption, cellular binding, uptake and processing of nanomedicines

2. Pharmaceutical Development

  • Delivery system and dosage form design for targeted drug delivery
  • Novel pharmaceutical process development for scaleability of nanomedicines
  • In vitro and in vivo models of drug delivery

3. Clinical Applications: Dermatology, Ophthalmology, Cancer, Immunology

  • Gene therapy
  • Vaccines: human and veterinary
  • Glaucoma and other neural degenerative disorders
  • HPV infections, treatment of LSIL/CIN I and cervical cancer prevention
  • Scleroderma (cutaneous)

4. Nanotoxicology

  • Nanomaterials as functional excipients
  • Systems Nanotoxicology
  • In vitro 3D cell culture model
  • Bioimaging
  • Biomarker search
  • Nanomedicine safety