Biphasix™ is a needle-free, noninvasive, particulate drug delivery system suitable for intra- and transdermal delivery of drugs. It is the next generation of liposomal drug delivery, where a number of liposomal characteristics have been greatly improved.
Biphasic vesicles are a complex, multicompartmental system, in which lipid bilayers entrap both aqueous and oil phases in a stabilized emulsion. They combine the advantages of liposomes with those of submicron emulsions.
The two important characteristics of the delivery system are
- improved drug encapsulation
- drug permeation enhancement through the skin
Drugs with poor solubility can be encapsulated in the multicompartments of the Biphasix™ delivery system. Biphasix™ can encapsulate compounds of high molecular weight. Results to date demonstrate successful encapsulation of proteins up to 100 kDa.
The Biphasix™ delivery system forms the basis of several topical and transdermal product applications, from the delivery of small molecules and protein drugs to vaccine antigens.