Dr. Andrea Edginton, Dr. Shinya Ito (SickKids, Toronto) and Dr. Julie Autmizguine (St. Justine Hospital, Montreal) received a 4-year $680,000 CIHR Project grant awarded in Spring 2018. The project abstract is as follows:
"Predicting escitalopram exposure to breastfeeding infants: integrating analytical and in silico techniques", has been accepted for publication in Clinical Pharmacokinetics.
This manuscript presents a workflow for integrating breastmilk concentrations, feeding schedules and infant exposure through physiologically-based pharmacokinetic modelling for the purpose of hazard assessment. The work is the collaboration of SickKids in Toronto and The Pharmacokinetics Research Group (Edginton) at University of Waterloo.
Dr. Alfonso Iorio (McMaster) (NPA), Dr. Andrea Edginton (PA), Dr. Man Chiu Poon (U Calgary) (PA) received a 3-yr project grant (Fall 2017 competition) entitled:
Personalized Medicine for Canadians with Hemophilia: a pragmatic evaluation of Web-Accessible Population Pharmacokinetics Service-Hemophilia (WAPPS-hemo) tailored dosing
This research will evaluate the effectiveness, safety and economics of the WAPPS-Hemo platform (www.wapps-hemo.org) in personalizing hemophilia treatment through pharmacokinetic modeling at 5 Canadian hemophilia centres.
Dr. Edginton has been invited to the Bill & Melinda Gates Medical Research Institute event -- 2018 PD Challenge Workshop: Collaborating to Improve Translational Medicine in Global Health being held April 26-27, 2018 at the Boston Marriott Copley Place.
The 2018 American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting is in Orlando, FL on March 21-24. The following abstracts will be presented:
Malik PRV, Edginton AN. Pediatric physiology in relation to the disposition of monoclonal antibodies.
Dr. Edginton will moderate a two hour workshop on pharmacokinetics in hemophilia at the 9th Annual Bayer Hemophilia Conference. The conference runs from November 2-4, 2017 in Amsterdam, NL.
“Drugs in Lactation” Analysis Consortium (DLAC)
A new website has been created to aid in recruitment of breastfeeding mothers for the DLAC project (www.thedlac.com).
See the University of Waterloo, School of Pharmacy Facebook page (https://www.facebook.com/UWPharmacy/) to hear PhD candidate, Paul Malik, speak about his research using mathematical models to analyze how cancer drug concentrations change in the body over time in virtual children.
Dr. Pierre Chelle has joined the Edginton lab as a postdoctoral fellow.
Dr. Chelle recently completed his PhD at the Ecole Nationale Supérieure des Mines de Saint-Etienne, Saint-Etienne, France. The subject of his thesis was: Thrombin generation modeling in the framework of hemophilia treatment.
Dr. Edginton is a member of the “Drugs in Lactation” Analysis Consortium (DLAC). DLACis a network of scientists who explore drug safety during breastfeeding. The network is designed for collection of patient breast milk samples in a real world setting, to generate pharmacokinetic information (how drugs are absorbed, distributed in body and metabolized). This information enables the researchers to predict drug levels in human milk and infant blood in a population.
DLAC is headed by Dr. Shinya Ito and is housed at SickKids in Toronto, ON, Canada.