News

Alanna McEneny-King successfully defended her PhD thesis “Pharmacokinetic modelling of clinically relevant situations in the treatment of hemophilia A and B “on Jan 23^rd, 2020. The thesis work explored the development and application of population pharmacokinetic models in the dose optimization of factor concentrates in hemophilia patients. The thesis also greatly contributed to the Web-Accessible Population Pharmacokinetic Service – Hemophilia (WAPPS-Hemo.org).

A big congratulations to Cindy, Simon and Paul on the publication of their manuscript Quantifying breast milk intake by term and preterm for input into pediatric physiologically-based pharmacokinetic models in Maternal and Child Nutrition.  

This is a great accomplishment for the lab and we are all very proud of your work and achievements!

Dr. Edginton has been featured in the Fall 2019 University of Waterloo Magazine.  To see the article about her current research, click here. 

Dr. Edginton has been invited as a tutor and presenter for the LAPKB workshop; The Introduction on population and PBPK Modeling Pmetrics and PK-Sim in the beautiful Beverly Hills, California. 

March 25 - 27, 2020.

Program Itinerary 

The manuscript for  "Open Systems Pharmacology community - an open access, open source, open science approach to modeling and simulation in pharmaceutical sciences" was accepted for publication in CPT: Pharmacometrics & Systems Pharmacology on September 23, 2019.  

The Grand Challenges 2018 Annual Meeting (Oct 15-18, 2018) featured a panel on PBPK modeling and simulation in advancing drug development in global health. Dr. Edginton was invited by the Bill & Melinda Gates Foundation to participate along with:

Congratulations to Paul Malik for receiving a three year CIHR Doctoral Scholarship ($105,000 over three years). The tenure of the award is 2018-2021.

Andrea Edginton PhD, Michael Neely, MD (University of Southern California) and Joerg Lippert PhD (Bayer, Germany) receive a US FDA grant ($900,000 US 2018-2021) on PBPK and Population Modeling Seamlessly Linked to Clinical Trial Simulation in an Open-Source Software Platform.

Dr. Andrea Edginton, Dr. Shinya Ito (SickKids, Toronto) and Dr. Julie Autmizguine (St. Justine Hospital, Montreal) received a 4-year $680,000 CIHR Project grant awarded in Spring 2018. The project abstract is as follows:

"Predicting escitalopram exposure to breastfeeding infants: integrating analytical and in silico techniques", has been accepted for publication in Clinical Pharmacokinetics.

This manuscript presents a workflow for integrating breastmilk concentrations, feeding schedules and infant exposure through physiologically-based pharmacokinetic modelling for the purpose of hazard assessment. The work is the collaboration of SickKids in Toronto and The Pharmacokinetics Research Group (Edginton) at University of Waterloo.