2024 Provost’s Program Black and Indigenous Postdoctoral Scholar: Emmanuel Okeke (he/him)

As a postdoctoral fellow at the University of Waterloo, my work focuses on understanding the complex causes of Alzheimer's disease (AD), a devastating condition affecting millions worldwide, including over half a million Canadians. Despite significant research efforts, the exact mechanisms leading to AD remain unclear, and current treatments are ineffective. My research aims to bridge this knowledge gap by exploring the interplay between lifestyle factors, environmental toxins, and neurotransmitters (chemical messengers in the brain) in the development of AD. I will investigate how these factors influence the behavior of a key protein called Amyloid beta (Aβ), which is implicated in AD pathology. Using a multidisciplinary approach, combining cell biology, environmental toxicology, epidemiology, and biophysics, I will study how neurotransmitters affect Aβ's impact on brain cells. I will also examine how exposure to toxic substances and certain drugs can either exacerbate or protect against Aβ-induced damage. 

By shedding light on these complex interactions, my research will provide crucial insights into the development of AD, ultimately contributing to the development of effective prevention and treatment strategies. This work embodies the postdoctoral program's spirit by: 

• Addressing a pressing health issue with significant societal impact 
• Embracing an interdisciplinary approach to tackle complex research questions 
• Pursuing innovative and high-impact research with potential for breakthrough discoveries 
• Demonstrating a commitment to advancing knowledge and improving human health 

My research has the potential to meaningfully change the lives of individuals and families affected by Alzheimer's disease, aligning with the postdoctoral program's goals of fostering innovative research and nurturing future leaders in their fields. 

During my time as a postdoctoral scholar at the University of Waterloo, I hope to accomplish the following: 

1. Advance our understanding of the complex mechanisms underlying Alzheimer's disease (AD), particularly the interplay between lifestyle factors, environmental toxins, and neurotransmitters. 
2. Investigate the role of neurotransmitters in Amyloid beta (Aβ) pathology and how environmental toxicants and drugs that modify neurotransmitter signaling may contribute to Aβ-induced neuronal dysfunction or provide protective effects. 
3. Provide crucial insights into the development of AD, which will ultimately contribute to the development of effective prevention and treatment strategies. 
4. Contribute to the development of innovative and impactful research in the field of Alzheimer's disease and neuroscience. 
5. Enhance my skills and expertise as a researcher, furthering my development as an independent investigator and future leader in your field. 
6. Collaborate with and learn from experienced researchers and experts in the field, expanding my professional network and building valuable connections. 
7. I will produce high-quality research outputs, including publications and presentations, to share my findings with the scientific community and beyond. 
8. Make a meaningful impact in the lives of individuals and families affected by Alzheimer's disease, driving positive change and improving human health. 

• Jiangsu University Presidential Scholarship awardee 2019, 2020, 2021, 2022 

During my Ph.D, I extensively investigated the neurodevelopmental toxicity and molecular mechanism of tetrabromobisphenol A bis(2-hydroxyethyl) ether (TBBPA-DHEE) on different life stages of Zebrafish. I have also conducted a number of studies on various emerging contaminants, especially microplastic pollution, and their effect on the human population. 

My choice of the University of Waterloo is due to several reasons; the University of Waterloo is known for its interdisciplinary research approach, which aligns with my project's requirement for a systems biology approach spanning multiple disciplines. The university has a strong reputation for research in neuroscience, toxicology, and environmental health, providing access to experienced researchers and state-of-the-art facilities. Additionally, the University of Waterloo fosters a collaborative research environment, allowing me to work with and learn from experts in various fields, including cell biology, environmental toxicology, epidemiology, and biophysics.

The university offers advanced research facilities, equipment, and resources, enabling me to conduct innovative and high-impact research. As a postdoctoral scholar at the University of Waterloo, I have access to training and development programs, workshops, and seminars to enhance my skills and prepare me for a successful research career. Furthermore, the university's location in Waterloo, Ontario, provides proximity to other research institutions, industries, and organizations, offering opportunities for collaboration, networking, and knowledge exchange. By choosing the University of Waterloo, I can leverage the institution's strengths and resources to achieve my research goals and advance my career as a postdoctoral scholar. 

I am most looking forward to being part of a vibrant and diverse community of postdoctoral scholars at the University of Waterloo. I am excited to collaborate with and learn from experienced researchers, share knowledge and ideas, and contribute to innovative research projects. I also look forward to developing my skills and expertise, expanding my professional network, and building lasting relationships with colleagues and mentors. Being part of this community will enable me to grow as a researcher, leader, and individual, and I am eager to contribute to and learn from this dynamic and supportive environment. 

In my spare time, I love playing football, taking a walk and going for picnics. 

• Connect with Emmanuel on LinkedIn
• Follow Emmanuel on X (formerly Twitter)