High intensity focused ultrasound (HIFU) has gained increasing attention as a noninvasive therapeutic method for wide range of biomedical applications from drug delivery to cancer treatment. However, high level of ultrasonic power required for efficient HIFU treatment can cause adverse effects such as damage to surrounding healthy tissues and skin burns. One of the strategies to improve the therapeutic mechanism of HIFU is to use ultrasound absorption agents during the treatment. The objectives of a current study are to investigate the feasibility of adopting nanoparticles and nanotubes to enhance the HIFU thermal ablation when they are injected locally to the focal region; and to understand the underlying physical mechanisms through analytical, numerical and experimental studies.
This research is conducted in collaboration with Prof. Hyock-Ju Kwon.
- A scheme of experimental setup of HIFU (in Waterloo Artificial Intelligence (AI) Ultrasonics Lab)
- Temperature rise diagram during the HIFU insonation and the effects of injected NPs at different power levels: (a) P=5 W; (b) P=8 W; and (c) P=12 W
Related publication
- Sadeghi-Goughari, M. ., Jeon, S. ., & Kwon, H.-J. . (2019). Enhancing Thermal Effect of Focused Ultrasound Therapy Using Gold Nanoparticles. IEEE Transactions on NanoBioscience, 18, 661-668.
- Sadeghi-Goughari, M. ., Jeon, S. ., & Kwon, H. J. (2020). Magnetic Nanoparticles-Enhanced Focused Ultrasound Heating: Size Effect, Mechanism, and Performance Analysis. Nanotechnology, 31.
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Sadeghi-Goughari, M. ., Jeon, S. ., & Kwon, H. J. (2020). Analytical and Numerical Model of High Intensity Focused Ultrasound Enhanced with Nanoparticles.