The Layton group is a diverse and interdisciplinary team of researchers using computational modeling tools to better understand aspects of renal physiology and pathophysiology. Mathematics is our microscope. We collaborate with physiologists, biomedical engineers, and clinicians to formulate detailed models of renal hemodynamics, transport, and metabolism. Model simulations and predictions are used to answer questions such as:

  • How should anti-hypertensive drugs be prescribed differently for men and women? 
  • A novel therapeutic treatment for lowering blood glucose level in diabetes targets the kidney. What are the potential side effects of this drug? 
  • How can we slow down the aging process?
  • Is it better to take ones medication in the morning or at night (or does it matter), given the interactions between the drug and our body's circadian rhythms?