Professor Bo Cui leads the Waterloo Nanofabrication Group whose research is focused on nano- and microstructure fabrication using Nano-Imprint Lithography (NIL) and electron beam lithography, thin film deposition and etching, with applications in biomedical, nanoelectric and other areas; this group is among the largest in Canada in the area of nanofabrication and clean room research.

Professor Cui focuses his research on plasmonic bio- and chemical sensors based on Extraordinary Optical Transmission (EOT), Surface Enhanced Raman Scattering (SERS) and localized Surface Plasmon Resonance (SPR). Professor Cui uses Nano-Imprint Lithography (NIL) to fabricate various novel nanostructured plasmonic bio- and chemical sensors. Professor Cui believes nanofabrication is a platform based on which the applications are limitless. In the biomedical area, the plasmonic bio-sensors fabricated by NIL can be employed to detect any bio-binding events (DNA hybridization, antibody-antigen binding), thus would find applications in pathogen (disease and crop) detection, etc.