Nonlinear vibration of nanobeam with the quadratic rational Bezier arc curvature is investigated. The governing equation of motion of the nanobeam based on the Euler-Bernoulli beam theory is developed. Accordingly, the non-uniform rational B-spline (NURBS) is implemented in order to write the implicit form of the governing equation of the structure. The simply-supported boundary conditions are assumed and the Galerkin procedure is utilized to find the nonlinear ordinary differential equation of the system. The nonlinear natural frequency of the system is found and the effects of different parameters, namely, the waviness amplitude, oscillation amplitude, aspect ratio, curvature shape and the Pasternak foundation coefficient are fully investigated. The hardening and softening responses of the natural frequency of structure are detected for variations of the shape and amplitude of the curvature waviness. It is revealed that the ratio of nonlinear to linear frequency increases with an increase in the oscillation amplitudes. It is found that by increasing the Pasternak foundation coefficient, the ratio of nonlinear to linear frequency decreases.