There are a vast number of researches in sensor networks, medical devices, wireless communication, middleware software and software applications that help advance improvements in the healthcare systems. Health monitoring systems deliver health status reports to actors such as people under monitoring, practitioners and coaches for several purposes. In this paper, we propose E-Ambulance framework, which is a smart ambulance system model that provides health monitoring of patients for remote medical professionals. As well as provide an automatic responses of suggestions and warnings to paramedic staff inside an ambulance. Sensor networks record and deliver health status information to other elements of system. Due to the availability of information from sensors networks, an auto response can take place by alarms supervised by Decision Maker unit. Remote decisions can be made in a medical center after receiving inputs generated inside an ambulance. Building a distributed real time system can handle all aspects of time critical systems and hide heterogeneity between elements and different types of data. Data Distribution Service (DDS) standard is used to build the proposed model. To demonstrate the effectiveness of the system in terms of latency and throughput, experiments are performed over DDS middleware. Additionally, to have efficient configuration different QoS policies configurations of DDS are tuned.