Chris Eliasmith, Director of the Centre for Theoretical Neuroscience, received the prestigious John C. Polanyi Award and is also an inaugural member of the Royal Society of Canada's College of New Scholars, Artists, and Scientists.
Departments of Mathematics and Anesthesiology
University of Michigan
Dynamics of Sleep-wake Regulation
Sleep and wake states are regulated by the interactions among a number of brainstem and hypothalamic neuronal populations and the expression of their neurotransmitters. Based on experimental studies, several different structures have been proposed for this sleep-wake regulatory network with particular debate over components involved in rapid-eye movement (REM) sleep regulation. We have developed a mathematical modeling framework that is uniquely suited for investigating the structure and dynamics of proposed sleep-wake regulatory networks. Using this framework, we are analyzing the competing proposed network structures for the regulation of REM sleep to determine how the structure of the sleep-wake regulatory network determines sleep-wake behavior and the dynamics of behavioral state transitions.
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