CTN Seminar Wilten Nicola, DC 1304
On Wednesday, April 22, 3:30 p.m. in DC 1304
Wilten Nicola, Hotchkiss Brain Institute, U Calgary (https://www.nicolacomputationalneurosciencelab.com/) will speak on
Title: Subthreshold Asynchronous States and Pattern Generation in Biophysically Detailed Populations of Neurons
Abstract: Learning with spikes is difficult. Spikes are metabolically costly and difficult to stabilize for computation. Here, we demonstrate that excitatory/inhibitory asynchronous states can exist without firing spikes through self-sustaining subthreshold voltage fluctuations in networks of biophysically detailed Hodgkin-Huxley neurons. This novel subthreshold asynchronous state, which we call voltage chaos, can be controlled for useful computation and pattern generation also without firing spikes. Our work here provides computational evidence for the existence of neural circuits that compute exclusively with subthreshold dynamics.