Malignant hyperthermia (MH) is a potentially fatal hypermetabolic condition triggered by certain anesthetics and caused by defective calcium homeostasis in skeletal muscle cells. Recent evidence has revealed impairment of various biochemical pathways in MHsusceptible patients in the absence of anesthetics. We hypothesized that clinical differences between MHsusceptible and control individuals are reflected in measurable differences in myoplasmic metabolites.
Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients. B. Bojko, T. Vasiljevic, E. Boyaci, A. Roszkowska, N. Kraeva, C. Ibarra Moreno, A. Koivu, M. Wasowicz, A. Hanna, S. Hamilton, S. Riazi, J. Pawliszyn. Can J Anesth XXX, XXX-XXX (2021) doi.org/10.1007/s12630-020-01895-y