Waterloo startup: Biosensor will detect post-op complications

NERv is developing a biodegradable biosensor that will give doctors early warning of infection or bleeding after surgery 

By Annette Van Gerwen

Marketing and Strategic Communications

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Youssef Helwa wants to remove the fear factor from those stressful weeks after a patient undergoes surgery.

To help prevent post-operative complications, he and a team of University of Waterloo entrepreneurs are developing a tiny biosensor that would be left inside the body to alert doctors to bleeding or infection.

Internal bleeding and infection hard to detect

“Post-op complications are a major problem in healthcare right now. They are very hard to detect, and can sometimes become life-threatening,” says Helwa, a nanotechnology engineering student and co-founder of NERv, a startup that aims to develop a portable, implantable bio-lab. NERv is working out of Waterloo’s Velocity Science program, the University's new discovery space for companies focused on life and physical sciences.

(left to right) Amr Abdelgawad, Youssef Helwa

(left to right) NERv partners Amr Abdelgawad and Youssef Helwa

The device will essentially be a nano-sized lab capable of assessing and providing feedback to doctors as patients go about their daily activities after surgery, says Helwa.

The team’s initial focus is on abdominal surgeries, such as those involving the liver, kidneys and intestines. The biosensor will detect biomarkers in the body that signal, for example, the start of an infection, hemorrhaging, or ischemia, a serious complication of inadequate blood flow to an organ.

NERv is targeting abdominal surgery because diagnosing complications after non-invasive abdominal surgery is challenging and expensive, says Helwa, adding that statistics show one in four abdominal surgery patient suffer post-op complications.

Biosensor is biodegradable

The biosensor itself is about a centimetre in diameter and is designed to be implanted inside a patient before their surgery is completed. Made of biocompatible and biodegradable materials, the small device won’t harm the body and can last up to a month before it starts to biodegrade.

“The highest risk for complications is within the first month following surgery,” Helwa says. 

If a problem is detected, the NERv device sends an alert to the doctor or patient on their mobile device. The message may include a description of the complication, its location and severity. If a patient has been discharged from the hospital, the system can be set to notify them on their mobile device to see their doctor immediately.

"Early detection and immediate action are key,” says Helwa.