Online Textbook

Mathematical Modeling in Systems Biology: An Introduction
Brian Ingalls


This text provides an introduction to dynamic mathematical modeling of cellular processes. The emphasis is on using computational tools to investigate models of cellular phenomena. Discussion of simple biochemical networks serves to illustrate some basic analytic techniques (including separation of time scales, phase plane analysis, and bifurcation analysis). The text then addresses models in four biological domains: metabolic networks, signal transduction pathways, gene regulatory networks and electrophysiology.